WDFY3 and TRIM39

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		WDFY3	TRIM39
Description		WD repeat and FYVE domain containing 3	tripartite motif containing 39
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GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Nuclear Envelope Nucleoplasm Nucleolus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Inclusion Body PML Body Axon Nuclear Membrane Atg12-Atg5-Atg16 Complex Cell Projection Perikaryon	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Lipid Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagy Macroautophagy Aggrephagy	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Monocyte percentage of white cells ( 32888494) Oropharynx cancer ( 27749845)	Anxiety ( 33859377) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)
Interacting Genes		16 interacting genes: ATG5 BTG3 CEP76 GABARAPL1 GABARAPL2 GRB2 MAP1LC3C MDFI PRMT1 PRMT6 RABGAP1L STAT3 SUV39H1 TNS2 TRIM39 ZBTB44	61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26
Entrez ID		23001	56658
HPRD ID		10304	09298
Ensembl ID		ENSG00000163625	ENSG00000204599
Uniprot IDs		Q8IZQ1	A0A024RCP5 Q9HCM9
PDB IDs		3WIM 6W9N	2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Mitophagy Phosphatidylethanolamine Binding Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Cellular Response To Stress Response To Nutrient Levels Histone Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Macroautophagy Autophagosome Maturation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Vacuole Organization Autophagosome Membrane Protein-arginine N-methyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Aggrephagy Response To Stress GABA Receptor Binding Autophagy Negative Regulation Of Protein Metabolic Process Phospholipid Binding Histone H3 Methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Proteolysis Protein-containing Complex Disassembly Negative Regulation Of Catabolic Process Organelle Assembly Methyltransferase Activity Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation DNA Damage Response Beta-tubulin Binding Protein Sequestering Activity Methylation Cytoplasmic Vesicle Guanyl-nucleotide Exchange Factor Adaptor Activity GATOR1 Complex Binding Histone H2AR3 Methyltransferase Activity Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Myeloid Cell Differentiation Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Catabolic Process Nucleus Protein Binding Nucleoplasm Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Ubiquitin Binding Regulation Of Post-translational Protein Modification Ubiquitin Ligase Complex Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Modification Process Cysteine-type Deubiquitinase Activity Transferase Activity Protein Deubiquitination Positive Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Negative Regulation Of Protein Deubiquitination ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex DNA Repair Cytosol Protein K6-linked Ubiquitination Protein Autoubiquitination Positive Regulation Of Protein Metabolic Process
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