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WDFY3 and ATG5
Number of citations of the paper that reports this interaction (PMID
20417604
)
53
Data Source:
BioGRID
(affinity chromatography technology, pull down)
WDFY3
ATG5
Gene Name
WD repeat and FYVE domain containing 3
autophagy related 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Envelope
Cytoplasm
Autophagic Vacuole
Inclusion Body
PML Body
Extrinsic Component Of Membrane
Nuclear Membrane
Atg12-Atg5-Atg16 Complex
Extrinsic Component Of Autophagic Vacuole Membrane
Cytoplasm
Autophagic Vacuole
Axoneme
Membrane
Pre-autophagosomal Structure Membrane
Atg12-Atg5-Atg16 Complex
ER-mitochondrion Membrane Contact Site
Molecular Function
Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity
Protein Binding
1-phosphatidylinositol Binding
Metal Ion Binding
Protein Binding
Atg8 Ligase Activity
Biological Process
Endosomal Transport
Positive Regulation Of Macroautophagy
Aggrephagy
Autophagic Vacuole Assembly
Mitochondrion Degradation
Blood Vessel Remodeling
Regulation Of Cytokine Secretion Involved In Immune Response
C-terminal Protein Lipidation
Autophagy
Apoptotic Process
Cellular Response To Nitrogen Starvation
Response To Fungus
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Type I Interferon Production
Negative Stranded Viral RNA Replication
Vasodilation
Response To Drug
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Nucleophagy
Innate Immune Response
Otolith Development
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Ventricular Cardiac Muscle Cell Development
Heart Contraction
Positive Regulation Of Mucus Secretion
Regulation Of Cilium Assembly
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Histone H4-K16 Acetylation
Pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Negative regulators of RIG-I/MDA5 signaling
Innate Immune System
Drugs
Diseases
GWAS
Systemic lupus erythematosus (
23273568
19838193
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Protein-Protein Interactions
7 interactors:
ATG5
CEP76
PRMT1
PRMT6
SUV39H1
TRIM39
ZBTB44
11 interactors:
ATG10
ATG12
ATG16L1
ATG3
CCHCR1
FADD
KEAP1
MEOX2
TEKT4
VCP
WDFY3
Entrez ID
23001
9474
HPRD ID
10304
16051
Ensembl ID
ENSG00000163625
ENSG00000057663
Uniprot IDs
Q8IZQ1
A9UGY9
Q9H1Y0
PDB IDs
4GDK
4GDL
Enriched GO Terms of Interacting Partners
?
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Histone Methylation
Peptidyl-arginine N-methylation
Histone H4-R3 Methylation
Histone Arginine Methylation
Peptidyl-arginine Methylation
Protein Methylation
Histone Modification
Methylation
Negative Regulation Of Protein Ubiquitination
Viral Process
Chromatin Modification
Histone H3-R2 Methylation
Organelle Organization
Cellular Protein Modification Process
Chromatin Organization
Negative Regulation Of Megakaryocyte Differentiation
Regulation Of Protein Ubiquitination
Negative Regulation Of Cellular Metabolic Process
Otolith Development
Histone H3-K9 Dimethylation
Peptidyl-amino Acid Modification
Negative Regulation Of Histone H4-K16 Acetylation
Chromosome Organization
Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
Negative Regulation Of Histone H4 Acetylation
RNA Biosynthetic Process
Cellular Protein Metabolic Process
Histone H3-K9 Trimethylation
Regulation Of Centriole Replication
Peptidyl-lysine Dimethylation
Negative Stranded Viral RNA Replication
Regulation Of Cytokine Secretion Involved In Immune Response
Chromatin Silencing At RDNA
Regulation Of Histone H4 Acetylation
Positive Regulation Of Mucus Secretion
Cellular Response To Nitrogen Starvation
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Megakaryocyte Differentiation
Regulation Of Mucus Secretion
Ventricular Cardiac Muscle Cell Development
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Histone Acetylation
Nucleophagy
Histone H3-K9 Methylation
Regulation Of Cilium Assembly
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Protein Acetylation
Autophagy
Macroautophagy
Cellular Response To Starvation
Autophagic Vacuole Assembly
Cellular Response To Nutrient Levels
Response To Starvation
Cellular Response To Extracellular Stimulus
Catabolic Process
Vacuole Organization
Cellular Response To Stress
Response To Nutrient Levels
Response To Extracellular Stimulus
Nucleophagy
Mitochondrion Degradation
Protein Modification By Small Protein Conjugation
Organelle Disassembly
Protein Transport
Response To Stress
Positive Regulation Of Proteolysis
Establishment Of Protein Localization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Neuron Death
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Autophagy In Response To ER Overload
Aggrephagy
Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Lys63-specific Deubiquitinase Activity
Positive Regulation Of Protein K63-linked Deubiquitination
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To External Stimulus
Activation Of Cysteine-type Endopeptidase Activity
Protein Oligomerization
Motor Neuron Apoptotic Process
Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation
Cell Death
Cellular Component Assembly
Death
Protein Localization
Zymogen Activation
ER-nucleus Signaling Pathway
Protein Lipidation
Organelle Assembly
Positive Regulation Of Cellular Protein Metabolic Process
Lipoprotein Biosynthetic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Endopeptidase Activity
Tagcloud
?
akt1
antipsychotic
atg12
atg4b
atg7
autophagic
autophagosome
autophagosomes
autophagy
bak1
bcl2l11
becn1
cdkn1a
cdkn1b
chloroquine
colocalization
dysfunctional
gabarap
henceforth
lc3b
map1lc3b
olanzapine
overtly
pmaip1
sqstm1
sy5y
trp53
unmask
Tagcloud (Difference)
?
akt1
antipsychotic
atg12
atg4b
atg7
autophagic
autophagosome
autophagosomes
autophagy
bak1
bcl2l11
becn1
cdkn1a
cdkn1b
chloroquine
colocalization
dysfunctional
gabarap
henceforth
lc3b
map1lc3b
olanzapine
overtly
pmaip1
sqstm1
sy5y
trp53
unmask
Tagcloud (Intersection)
?