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WDFY3 and ATG5
Number of citations of the paper that reports this interaction (PubMedID
20417604
)
58
Data Source:
BioGRID
(affinity chromatography technology, pull down)
WDFY3
ATG5
Description
WD repeat and FYVE domain containing 3
autophagy related 5
Image
GO Annotations
Cellular Component
Autophagosome Membrane
Nucleus
Nuclear Envelope
Nucleoplasm
Nucleolus
Cytoplasm
Autophagosome
Cytosol
Plasma Membrane
Membrane
Inclusion Body
PML Body
Axon
Nuclear Membrane
Atg12-Atg5-Atg16 Complex
Cell Projection
Perikaryon
Cytoplasm
Autophagosome
Cytosol
Axoneme
Membrane
Axon
Phagocytic Vesicle Membrane
Protein-containing Complex
Phagophore Assembly Site Membrane
Atg12-Atg5-Atg16 Complex
Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
Synapse
Phagophore
Schaffer Collateral - CA1 Synapse
Postsynapse
Glutamatergic Synapse
Transferase Complex
Molecular Function
Protein Binding
1-phosphatidylinositol Binding
Zinc Ion Binding
Lipid Binding
Metal Ion Binding
Protein Binding
Atg8-family Ligase Activity
Biological Process
Autophagy
Macroautophagy
Aggrephagy
Autophagosome Assembly
Mitophagy
Blood Vessel Remodeling
Immune System Process
Regulation Of Cytokine Production Involved In Immune Response
Chromatin Organization
Autophagy
Apoptotic Process
Cellular Response To Nitrogen Starvation
Cellular Response To Starvation
Response To Xenobiotic Stimulus
Response To Fungus
Response To Iron(II) Ion
Positive Regulation Of Autophagy
Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Macroautophagy
Protein Ubiquitination
Antigen Processing And Presentation Of Endogenous Antigen
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Type I Interferon Production
Piecemeal Microautophagy Of The Nucleus
Aggrephagy
Negative Stranded Viral RNA Replication
Vasodilation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Post-translational Protein Modification
Negative Thymic T Cell Selection
Innate Immune Response
Negative Regulation Of Innate Immune Response
Otolith Development
Negative Regulation Of Defense Response To Virus
Negative Regulation Of Phagocytosis
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Defense Response To Virus
Establishment Of Localization In Cell
Ventricular Cardiac Muscle Cell Development
Heart Contraction
Chaperone-mediated Autophagy
Positive Regulation Of Stress Granule Assembly
Mucus Secretion
Positive Regulation Of Mucus Secretion
Cellular Response To Nitrosative Stress
Axonal Transport
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Postsynaptic Modulation Of Chemical Synaptic Transmission
Regulation Of Autophagosome Maturation
Regulation Of Cilium Assembly
Response To Fluoride
Negative Regulation Of Autophagic Cell Death
Positive Regulation Of Viral Translation
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Macroautophagy
PINK1-PRKN Mediated Mitophagy
Receptor Mediated Mitophagy
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Cerebral amyloid deposition (PET imaging) (
26252872
)
Monocyte percentage of white cells (
32888494
)
Oropharynx cancer (
27749845
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Glucose homeostasis traits (
25524916
)
Limited cutaneous systemic scleroderma (
24387989
)
Monobrow (
27182965
)
Multiple myeloma (
33875642
27363682
)
Rheumatoid arthritis (
24390342
30423114
)
Systemic lupus erythematosus (
28714469
19838193
27399966
26502338
23273568
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Systemic sclerosis (
31672989
24387989
)
Visceral fat (
30942860
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
16 interacting genes:
ATG5
BTG3
CEP76
GABARAPL1
GABARAPL2
GRB2
MAP1LC3C
MDFI
PRMT1
PRMT6
RABGAP1L
STAT3
SUV39H1
TNS2
TRIM39
ZBTB44
31 interacting genes:
ATG10
ATG12
ATG16L1
ATG16L2
ATP23
CALCOCO2
CAPN1
CAPN2
CCHCR1
FADD
FMR1
GRIPAP1
HOOK2
INCA1
IRGM
KEAP1
KIAA1328
MAD1L1
MEOX2
MYC
NLRP6
OPTN
PSMB11
RACK1
TECPR1
TEKT4
TIAM1
TRIM21
USP13
VCP
WDFY3
Entrez ID
23001
9474
HPRD ID
10304
16051
Ensembl ID
ENSG00000163625
ENSG00000057663
Uniprot IDs
Q8IZQ1
A0A2R8Y718
A9UGY9
Q7Z3H3
Q9H1Y0
PDB IDs
3WIM
6W9N
4GDK
4GDL
4NAW
4TQ0
4TQ1
5D7G
5NPV
5NPW
7W36
Enriched GO Terms of Interacting Partners
?
Cellular Response To Nitrogen Starvation
Cellular Response To Starvation
Response To Starvation
Cellular Response To Nutrient Levels
Mitophagy
Phosphatidylethanolamine Binding
Autophagy Of Mitochondrion
Autophagosome
Autophagosome Assembly
Autophagosome Organization
Cellular Response To Stress
Response To Nutrient Levels
Histone Methyltransferase Activity
Protein-arginine Omega-N Monomethyltransferase Activity
Histone H4R3 Methyltransferase Activity
Macroautophagy
Autophagosome Maturation
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Vacuole Organization
Autophagosome Membrane
Protein-arginine N-methyltransferase Activity
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Aggrephagy
Response To Stress
GABA Receptor Binding
Autophagy
Negative Regulation Of Protein Metabolic Process
Phospholipid Binding
Histone H3 Methyltransferase Activity
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Proteolysis
Protein-containing Complex Disassembly
Negative Regulation Of Catabolic Process
Organelle Assembly
Methyltransferase Activity
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
DNA Damage Response
Beta-tubulin Binding
Protein Sequestering Activity
Methylation
Cytoplasmic Vesicle
Guanyl-nucleotide Exchange Factor Adaptor Activity
GATOR1 Complex Binding
Histone H2AR3 Methyltransferase Activity
Regulation Of Erythrocyte Differentiation
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Myeloid Cell Differentiation
Cytoplasm
Negative Regulation Of Proteasomal Protein Catabolic Process
Autophagy
Macroautophagy
Regulation Of Autophagy
Autophagosome
Atg12-Atg5-Atg16 Complex
Catabolic Process
Autophagosome Membrane
Regulation Of Autophagosome Maturation
Autophagosome Assembly
Cytosol
Vacuole Organization
Positive Regulation Of Catabolic Process
Autophagosome Organization
Cytoplasm
Protein-containing Complex Disassembly
Identical Protein Binding
Regulation Of Macroautophagy
Positive Regulation Of Proteolysis
Positive Regulation Of Proteasomal Protein Catabolic Process
Autophagosome Maturation
C-terminal Protein Lipidation
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Viral Genome Replication
Phagophore Assembly Site Membrane
Macromolecule Catabolic Process
Negative Stranded Viral RNA Replication
Signaling Adaptor Activity
Protein Transport
Positive Regulation Of Autophagy
Calpain Complex
BAT3 Complex Binding
Regulation Of Proteasomal Protein Catabolic Process
Organelle Assembly
Protein-containing Complex Binding
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Immune System Process
BH3 Domain Binding
Regulation Of Proteolysis
Establishment Of Protein Localization
Response To Virus
Stress Granule Disassembly
Xenophagy
Positive Regulation Of Autophagosome Maturation
Viral RNA Genome Replication
Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Xenophagy
Post-translational Protein Modification
Protein Catabolic Process
Positive Regulation Of Cellular Component Organization
Protein-containing Complex Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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