NINL and MCM10

Number of citations of the paper that reports this interaction (PubMedID 26638075)
45

Data Source:
BioGRID (two hybrid, proximity labelling technology)
HPRD (two hybrid)

		NINL	MCM10
Description		ninein like	minichromosome maintenance 10 replication initiation factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule	Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	DNA Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Microtubule Anchoring At Centrosome	DNA Replication DNA Replication Initiation DNA Damage Response Cell Population Proliferation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Telomere length ( 30185882) Urate levels ( 31578528)	Nicotine dependence symptom count ( 25555482) Survival time in esophageal squamous cell carcinoma ( 34185429)
Interacting Genes		52 interacting genes: AKAP17A APEX2 AURKB CBY2 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA ERBB2 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 PRPF18 PRPF3 RBM41 RCOR3 RGS2 RIBC2 RNF40 SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSC1 TSPYL4 UTP14A YJU2B ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646	37 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A
Entrez ID		22981	55388
HPRD ID		11120	11297
Ensembl ID		ENSG00000101004	ENSG00000065328
Uniprot IDs		Q9Y2I6	Q7L590
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Pole Nucleus Protein Binding Chromosome, Centromeric Region Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Pole Regulation Of Metaphase Plate Congression Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Positive Regulation Of Chromosome Segregation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H4K16 Acetyltransferase Activity Spindle Microtubule Protein Localization To Chromosome Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cytoskeleton Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Negative Regulation Of Cell Cycle Phase Transition Zinc Ion Binding Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation RNA Splicing Centrosome	DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Origin Binding CMG Complex Regulation Of DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region MCM Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Stress DNA Damage Response Origin Recognition Complex Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle DNA Recombination G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Nucleus Regulation Of Cell Cycle Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding Cell Division Cyclin D1-CDK6 Complex Cyclin D3-CDK6 Complex DNA Replication Preinitiation Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Single-stranded DNA Helicase Activity Centrosome Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Helicase Activity DNA Repair Protein Serine/threonine Kinase Binding Mitotic Cell Cycle Phase Transition Cytoplasm Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cell Cycle Process Cell Cycle Phase Transition
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