MCM10 and DPPA2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MCM10	DPPA2
Description		minichromosome maintenance 10 replication initiation factor	developmental pluripotency associated 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork	Nucleus Nucleoplasm
	Molecular Function	DNA Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Chromatin Binding Protein Binding
	Biological Process	DNA Replication DNA Replication Initiation DNA Damage Response Cell Population Proliferation	System Development
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS		Nicotine dependence symptom count ( 25555482) Survival time in esophageal squamous cell carcinoma ( 34185429)	Corneal astigmatism ( 23761726) Spatial memory ( 31596458)
Interacting Genes		37 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A	19 interacting genes: AP2M1 DPPA4 DVL2 DVL3 EIF1AD FGF12 FXR2 MCM10 MOAP1 PBXIP1 PLOD3 SDCBP2 SETD5 SPOP U2AF2 UBE2I VTA1 ZCCHC10 ZNF250
Entrez ID		55388	151871
HPRD ID		11297	13248
Ensembl ID		ENSG00000065328	ENSG00000163530
Uniprot IDs		Q7L590	Q7Z7J5
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Origin Binding CMG Complex Regulation Of DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region MCM Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Stress DNA Damage Response Origin Recognition Complex Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle DNA Recombination G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Nucleus Regulation Of Cell Cycle Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding Cell Division Cyclin D1-CDK6 Complex Cyclin D3-CDK6 Complex DNA Replication Preinitiation Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Single-stranded DNA Helicase Activity Centrosome Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Helicase Activity DNA Repair Protein Serine/threonine Kinase Binding Mitotic Cell Cycle Phase Transition Cytoplasm Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cell Cycle Process Cell Cycle Phase Transition	Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization
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