MCM10 and CCND1

Number of citations of the paper that reports this interaction (PMID 15232106)
88

Data Source:
HPRD (in vitro)

		MCM10	CCND1
Gene Name		minichromosome maintenance complex component 10	cyclin D1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Intracellular Nucleus Nucleoplasm Cytosol Tight Junction Membrane Transcriptional Repressor Complex
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding Proline-rich Region Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Cell Proliferation	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Liver Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Response To Corticosterone Response To Calcium Ion Canonical Wnt Signaling Pathway Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest
Pathways		G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex Cell Cycle, Mitotic G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases	Chromatin organization Signaling by NOTCH Ubiquitin-dependent degradation of Cyclin D G1 Phase S Phase Cell Cycle, Mitotic RMTs methylate histone arginines Ubiquitin-dependent degradation of Cyclin D1 Cyclin D associated events in G1 Chromatin modifying enzymes Pre-NOTCH Transcription and Translation Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases
Drugs			Arsenic trioxide
Diseases
GWAS			Breast cancer ( 20453838) Breast size ( 22747683) Multiple myeloma (IgH translocation) ( 23502783)
Protein-Protein Interactions		32 interactors: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 TRIM37 VPRBP ZBTB43 ZBTB8A	60 interactors: AKAP8 AR ARID4A ATF2 BRCA1 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CRYAB CTNNB1 CUL3 DMTF1 EP300 ESR1 FBXO31 FBXO4 GSK3B HDAC3 HERC5 IFI27 INSM1 KAT2B LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PRKACA RABEP1 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SP1 STAT3 TAF1 THRA THRB TP73 TSC2 UBTF UHRF2 USP2 XPO1
Entrez ID		55388	595
HPRD ID		11297	01346
Ensembl ID		ENSG00000065328	ENSG00000110092
Uniprot IDs		Q7L590	P24385 Q6FI00
PDB IDs			2W96 2W99 2W9F 2W9Z
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process DNA Replication Initiation DNA-dependent DNA Replication DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Unwinding Involved In DNA Replication Cellular Nitrogen Compound Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Cell Division Biosynthetic Process DNA Conformation Change Double-strand Break Repair Via Break-induced Replication Nitrogen Compound Metabolic Process Organelle Organization Chromosome Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Phosphorylation	Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Organic Substance Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Cycle Arrest Transcription, DNA-templated Cellular Response To Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Kinase Activity RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Kinase Activity Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process
Tagcloud ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold
Tagcloud (Difference) ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold
Tagcloud (Intersection) ?