MCM10 and CDKN1A

Number of citations of the paper that reports this interaction (PMID 15232106)
88

Data Source:
HPRD (in vitro)

		MCM10	CDKN1A
Gene Name		minichromosome maintenance complex component 10	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm PCNA-p21 Complex
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin-dependent Protein Kinase Activating Kinase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Cell Proliferation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Response To X-ray Response To Organonitrogen Compound Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Organ Regeneration Cellular Response To Extracellular Stimulus Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Phosphorylation Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Arsenic-containing Substance Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Response To Corticosterone Response To Hyperoxia Intestinal Epithelial Cell Maturation Cellular Response To Ionizing Radiation Cellular Response To UV-B Mitotic Cell Cycle Arrest Cellular Senescence Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex Cell Cycle, Mitotic G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Cellular Senescence p53-Dependent G1/S DNA damage checkpoint Cyclin E associated events during G1/S transition AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade G1/S Transition Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Signaling by PDGF DAP12 interactions DNA Damage/Telomere Stress Induced Senescence GAB1 signalosome Senescence-Associated Secretory Phenotype (SASP) S Phase Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR SCF(Skp2)-mediated degradation of p27/p21 Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Adaptive Immune System PIP3 activates AKT signaling Orc1 removal from chromatin p53-Dependent G1 DNA Damage Response PI3K events in ERBB2 signaling Transcriptional activation of p53 responsive genes Downstream signaling of activated FGFR G1/S DNA Damage Checkpoints Innate Immune System Transcriptional activation of cell cycle inhibitor p21 Signalling by NGF Synthesis of DNA G1 Phase Regulation of DNA replication Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Cell Cycle, Mitotic Signaling by FGFR Orc1 removal from chromatin Cyclin D associated events in G1 Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Colorectal cancer ( 22634755) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Ventricular conduction ( 21076409)
Protein-Protein Interactions		32 interactors: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 TRIM37 VPRBP ZBTB43 ZBTB8A	176 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AKT1 ALAS1 ANGPT2 APLP1 APP ATP5B ATP6V1A ATXN3 BAD BAG6 BCCIP C1orf123 CASP3 CCDC85B CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC42 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB DAPK3 DDAH2 DEAF1 DOCK7 DYNC1I1 EEF1A1 EP300 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB2L1 GNB5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HIST1H1B HMGXB3 HNRNPK HOXD8 HPD IKBKG IKZF3 ING5 INPP5K KLHL23 KMT2B KRT31 LATS2 LRIF1 MAP3K5 MAPK8 MCM10 MED31 MSH2 NGFR NKD2 NMRK2 NOV NPM1 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PSMA3 QARS RAB1A RAI1 RB1 RBBP4 RBM48 RNF126 RNF144B RPL18 RPL35 RPS2 S100A8 SDF4 SET SETDB1 SIPA1 SKP2 SLC25A11 SP110 SPRED1 STAT3 SUMO3 TAF5L TCF4 TEX11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TRAF1 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBC UBE2D1 UNC119 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431
Entrez ID		55388	1026
HPRD ID		11297	00298
Ensembl ID		ENSG00000065328	ENSG00000124762
Uniprot IDs		Q7L590	J3KQV0 P38936
PDB IDs			1AXC 2ZVV 2ZVW
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process DNA Replication Initiation DNA-dependent DNA Replication DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Unwinding Involved In DNA Replication Cellular Nitrogen Compound Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Cell Division Biosynthetic Process DNA Conformation Change Double-strand Break Repair Via Break-induced Replication Nitrogen Compound Metabolic Process Organelle Organization Chromosome Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Phosphorylation	Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Cell Cycle Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Phosphorylation Nitrogen Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Cell Death Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Division Regulation Of Protein Phosphorylation Organelle Organization Regulation Of Cellular Process Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Chromosome Organization Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Macromolecule Biosynthetic Process Biosynthetic Process Apoptotic Process Cell Death Death Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Response To Stress Cellular Response To Stimulus
Tagcloud ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	antigen arf cd24 competitively context e6 glioma hairpin inactivation mdm2 mutated mutates nearly npm oncogenes overexpressed p21 papilloma prevents prostate retard reveal shrna silencing silico somatic sv40 tp53 viral
Tagcloud (Difference) ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	antigen arf cd24 competitively context e6 glioma hairpin inactivation mdm2 mutated mutates nearly npm oncogenes overexpressed p21 papilloma prevents prostate retard reveal shrna silencing silico somatic sv40 tp53 viral
Tagcloud (Intersection) ?