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NINL and LZTS2
Number of citations of the paper that reports this interaction (PubMedID
26638075
)
45
Data Source:
BioGRID
(two hybrid, proximity labelling technology)
HPRD
(two hybrid)
NINL
LZTS2
Description
ninein like
leucine zipper tumor suppressor 2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Midbody
Vesicle
Molecular Function
Calcium Ion Binding
Protein Binding
Metal Ion Binding
Protein Binding
Biological Process
Microtubule Anchoring At Centrosome
Mitotic Cytokinesis
Kidney Development
Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Microtubule Severing
Nuclear Export
Spindle Midzone Assembly
Cell Division
Primary Ureteric Bud Growth
Ureter Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Nucleus
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Macular thickness (
30535121
)
Telomere length (
30185882
)
Urate levels (
31578528
)
Ejection fraction in Tripanosoma cruzi seropositivity (
24324551
)
Regular attendance at a pub or social club (
29970889
)
Interacting Genes
52 interacting genes:
AKAP17A
APEX2
AURKB
CBY2
CCDC146
CCDC33
CCHCR1
CLEC1B
DCTN5
ELOA
ERBB2
EWSR1
EZH2
FAM107A
FAM161A
GCC1
GPKOW
HAUS1
JUNB
KANSL1
KAT5
KAT7
KRT1
L3MBTL4
LRSAM1
LZTS2
MAD1L1
MBIP
MCM10
PLK1
PRPF18
PRPF3
RBM41
RCOR3
RGS2
RIBC2
RNF40
SH2D4A
SH3BP5L
SYT17
TCEANC
TNNT1
TSC1
TSPYL4
UTP14A
YJU2B
ZFC3H1
ZFHX3
ZNF250
ZNF417
ZNF426
ZNF646
220 interacting genes:
ABI2
ABT1
AEN
AIRIM
ANKRD11
ANKRD36BP1
AP1M1
ARMC7
ARNT2
ATOSB
ATPAF2
BAHD1
BEX2
BMS1P1
BYSL
C8orf33
CABP5
CARD9
CATSPER1
CATSPERT
CBX8
CCDC187
CCDC198
CCDC85B
CCNC
CCNG1
CCNK
CDC23
CDK18
CDKL3
CDKN1A
CEP57L1
CFAP206
CHCHD3
CHIC2
CLIP4
CNNM3
COPB1
CWF19L2
DCUN1D1
DGCR6
DGCR6L
DLG4
DUSP4
DYRK2
EHHADH
EIF3D
EIF4E2
EXOSC5
FAM107A
FAM124B
FAM161A
FAM221B
FAM50B
FAM74A4
FAM90A1
FANCL
FEM1C
FGF12
FKBP6
FNDC11
FRG1
FRMD6
FXR1
GADD45GIP1
GATA1
GCC1
GEM
GFI1B
GIPC2
GLIDR
GLYCTK
GMCL2
GNL3L
GPANK1
GPATCH2L
GRB2
HLA-DPB1
HM13
HOMER2
HOXB9
HSPD1
IGFN1
INO80B
IQCE
IQCN
KAT5
KAZN
KIF9
KIFC3
KPNA2
LASP1
LCK
LIN37
LMO1
LMO2
LMO3
MAB21L3
MAGEB4
MAPK1
MEMO1
MID2
MORF4L1
MORF4L2
MORN3
MOS
MTA1
MYOZ1
NCBP2
NCK2
NDE1
NEBL
NEK6
NINL
NIP7
NTAQ1
OTUB2
PAK5
PATZ1
PHF1
PHF19
PITX1
PKP4
PLEKHN1
POLDIP3
POLR1C
PPP1R16A
PPP1R18
PQBP1
PRKAA2
PRKAB2
PRPF18
PRPF31
PRR35
PSMA1
QARS1
RAC1
RAD51D
RAMAC
RBFOX1
RBM15
RBM41
RBPMS
RCOR3
RHNO1
RHOXF2
RIN1
RNF32
RNF41
RTP5
RUNX1T1
SCNM1
SH2D4A
SH3KBP1
SH3RF2
SHANK3
SHFL
SLC15A3
SLC25A6
SLC39A14
SLU7
SMARCB1
SMARCD1
SMIM3
SNHG11
SNW1
SNX31
SPATA24
SPATC1L
SPG7
SRSF2
STAC
SUPV3L1
SUV39H1
SYT17
TBC1D7
TCEA2
TEAD4
THAP10
THAP7
TLE5
TNIP3
TRAF2
TRIM29
TRIM42
TSC1
TSNAX
TSSK2
TSSK3
TTC23
TTLL10
TXNL4A
UBASH3A
UBASH3B
USF2
USP2
UTP14C
VEZF1
WT1-AS
YTHDC1
ZBTB25
ZBTB38
ZC2HC1C
ZGPAT
ZKSCAN3
ZMAT1
ZMAT2
ZMYND19
ZNF124
ZNF20
ZNF250
ZNF408
ZNF417
ZNF426
ZNF446
ZNF490
ZNF512B
ZNF572
ZNF581
ZNF648
Entrez ID
22981
84445
HPRD ID
11120
14341
Ensembl ID
ENSG00000101004
ENSG00000107816
Uniprot IDs
Q9Y2I6
B4DP66
Q9BRK4
PDB IDs
Enriched GO Terms of Interacting Partners
?
Mitotic Spindle Pole
Nucleus
Protein Binding
Chromosome, Centromeric Region
Positive Regulation Of Mitotic Sister Chromatid Segregation
Spindle Pole
Regulation Of Metaphase Plate Congression
Kinetochore
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Histone Acetyltransferase Complex
Positive Regulation Of Chromosome Segregation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Attachment Of Spindle Microtubules To Kinetochore
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Histone H4K16 Acetyltransferase Activity
Spindle Microtubule
Protein Localization To Chromosome
Regulation Of Sister Chromatid Segregation
Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Regulation Of RNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle
Cytoskeleton
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Spindle Midzone Assembly
Histone H4 Acetyltransferase Activity
Peptidyl-lysine Acetylation
Negative Regulation Of Cell Cycle Phase Transition
Zinc Ion Binding
Regulation Of Chromosome Segregation
Regulation Of Mitotic Sister Chromatid Separation
RNA Splicing
Centrosome
Protein Binding
Nucleus
Nucleoplasm
Zinc Ion Binding
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
MRNA Splicing, Via Spliceosome
Nuclear Speck
RNA Processing
RNA Splicing, Via Transesterification Reactions
RNA Splicing
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
MRNA Processing
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
DNA Binding
Nucleic Acid Metabolic Process
Alternative MRNA Splicing, Via Spliceosome
MRNA Metabolic Process
Transcription Coactivator Activity
Negative Regulation Of Macromolecule Metabolic Process
RNA Metabolic Process
TSC1-TSC2 Complex
Cellular Response To Nutrient Levels
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Tagcloud (Intersection)
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