MCM10 and HOOK2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MCM10	HOOK2
Gene Name		minichromosome maintenance complex component 10	hook microtubule-tethering protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Centrosome Microtubule HOPS Complex FHF Complex
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Cell Proliferation	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Early Endosome To Late Endosome Transport
Pathways		G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex Cell Cycle, Mitotic G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 TRIM37 VPRBP ZBTB43 ZBTB8A	31 interactors: ABLIM1 AKTIP ANKRD11 ANKRD36BP1 AP1M1 APEX2 CCDC33 CWF19L2 DUSP13 EPS8 FAM107A HOOK1 HOOK3 IQCE ITSN2 KANSL1 KAT7 KIAA0408 MCM10 PSMF1 RALBP1 RIBC2 SUV39H1 USP2 UTP14A UTP14C VPS16 VPS41 ZC2HC1C ZNF250 ZNF638
Entrez ID		55388	29911
HPRD ID		11297	09698
Ensembl ID		ENSG00000065328	ENSG00000095066
Uniprot IDs		Q7L590	Q96ED9
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process DNA Replication Initiation DNA-dependent DNA Replication DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Unwinding Involved In DNA Replication Cellular Nitrogen Compound Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Cell Division Biosynthetic Process DNA Conformation Change Double-strand Break Repair Via Break-induced Replication Nitrogen Compound Metabolic Process Organelle Organization Chromosome Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Phosphorylation	Early Endosome To Late Endosome Transport Vacuolar Transport Endosomal Transport Vacuole Organization Endosome To Lysosome Transport Endosome Organization Lysosomal Transport Regulation Of SNARE Complex Assembly Lysosome Organization Cell Cycle Histone H4-K5 Acetylation Histone H4-K8 Acetylation Organelle Organization RRNA Processing RRNA Metabolic Process Maturation Of SSU-rRNA Cytoplasmic Transport Regulation Of Vesicle Fusion Ribosomal Small Subunit Biogenesis Ribosome Biogenesis Regulation Of Vacuole Fusion, Non-autophagic Vacuole Fusion, Non-autophagic Histone H4 Acetylation Peptidyl-lysine Modification Viral Process Protein Transport Actin Polymerization-dependent Cell Motility Vesicle-mediated Transport Establishment Of Protein Localization
Tagcloud ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	accumulated approaches basic benign demonstrates encoding hmga hmga2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work
Tagcloud (Difference) ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	accumulated approaches basic benign demonstrates encoding hmga hmga2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work
Tagcloud (Intersection) ?