MCM10 and CDC7

Number of citations of the paper that reports this interaction (PMID 15232106)
88

Data Source:
HPRD (in vitro)

		MCM10	CDC7
Gene Name		minichromosome maintenance complex component 10	cell division cycle 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Cell Proliferation	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Phagocytosis Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division
Pathways		G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex Cell Cycle, Mitotic G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases	G1/S Transition G2/M Checkpoints Activation of ATR in response to replication stress Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Cell Cycle Checkpoints Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Optic disc parameters ( 20548946 21307088)
Protein-Protein Interactions		32 interactors: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 TRIM37 VPRBP ZBTB43 ZBTB8A	24 interactors: APP CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 GPT GRHPR MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC5 ORC6 TOB1
Entrez ID		55388	8317
HPRD ID		11297	10345
Ensembl ID		ENSG00000065328	ENSG00000097046
Uniprot IDs		Q7L590	B2R6V2 J3KQS2 O00311
PDB IDs			4F99 4F9A 4F9B 4F9C
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process DNA Replication Initiation DNA-dependent DNA Replication DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Unwinding Involved In DNA Replication Cellular Nitrogen Compound Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Cell Division Biosynthetic Process DNA Conformation Change Double-strand Break Repair Via Break-induced Replication Nitrogen Compound Metabolic Process Organelle Organization Chromosome Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Phosphorylation	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Replication Initiation DNA-dependent DNA Replication Cell Cycle Cell Cycle Process DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication DNA Conformation Change Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Chromosome Organization Macromolecule Biosynthetic Process Regulation Of Cell Cycle Arrest Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cellular Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Phosphorylation Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Arrest Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Cellular Response To Stress Organelle Organization Regulation Of Kinase Activity
Tagcloud ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	af ana antinuclear assignment beads blots cdc10 cdc2 cdc4 cdc5 cdc9 dilutions foundation immunodiffusion intensities jo monospecific originally purposes reagents reference rnp ro semiquantitative sera ss u1 weaker
Tagcloud (Difference) ?		cerevisiae deadpan delay discs driver drosophila enhancer eye eyes gal4 gmr imaginal interference involvement klingon knockdown lacz maintenance mini monitor morphology ommatidia phases photoreceptor r7 replication rough surprisingly	af ana antinuclear assignment beads blots cdc10 cdc2 cdc4 cdc5 cdc9 dilutions foundation immunodiffusion intensities jo monospecific originally purposes reagents reference rnp ro semiquantitative sera ss u1 weaker
Tagcloud (Intersection) ?