NINL and RNF40

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NINL	RNF40
Description		ninein like	ring finger protein 40
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane HULC Complex
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Anchoring At Centrosome	Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Telomere length ( 30185882) Urate levels ( 31578528)	Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		52 interacting genes: AKAP17A APEX2 AURKB CBY2 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA ERBB2 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 PRPF18 PRPF3 RBM41 RCOR3 RGS2 RIBC2 RNF40 SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSC1 TSPYL4 UTP14A YJU2B ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646	27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DUSP29 EEF1D H2AC4 H2BC3 ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL PKNOX1 RB1 RPA1 RPA2 TRIM51 UBE2A UBE2B UBE2D2 UBE2I UBE2L6 ZCCHC12 ZNF451
Entrez ID		22981	9810
HPRD ID		11120	07411
Ensembl ID		ENSG00000101004	ENSG00000103549
Uniprot IDs		Q9Y2I6	A8K6K1 O75150
PDB IDs			8GUI 8GUJ 8IEJ
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Pole Nucleus Protein Binding Chromosome, Centromeric Region Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Pole Regulation Of Metaphase Plate Congression Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Positive Regulation Of Chromosome Segregation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H4K16 Acetyltransferase Activity Spindle Microtubule Protein Localization To Chromosome Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cytoskeleton Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Negative Regulation Of Cell Cycle Phase Transition Zinc Ion Binding Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation RNA Splicing Centrosome	Ubiquitin Conjugating Enzyme Activity Protein Localization To Chromosome PML Body Ubiquitin-like Protein Transferase Activity Chromosome, Telomeric Region Positive Regulation Of MRNA 3'-end Processing HULC Complex Chromatin Organization Nucleus Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Modification By Small Protein Conjugation Protein Polyubiquitination Telomere Localization Regulation Of MRNA 3'-end Processing G-rich Strand Telomeric DNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition DNA Replication Factor A Complex Chromosome Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Site Of Double-strand Break Chromatin Remodeling Telomere Maintenance Proteolysis Involved In Protein Catabolic Process Histone MRNA Metabolic Process Response To Radiation Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Site Of Double-strand Break Sperm Axoneme Assembly Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Mismatch Repair Telomere Organization DNA Repair MRNA 3'-end Processing Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Recombinational Repair Regulation Of DNA Recombination Positive Regulation Of RNA Binding
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