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MCM10 and ORC3
Number of citations of the paper that reports this interaction (PMID
15232106
)
88
Data Source:
HPRD
(in vitro)
MCM10
ORC3
Gene Name
minichromosome maintenance complex component 10
origin recognition complex, subunit 3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Origin Recognition Complex
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Molecular Function
DNA Binding
Protein Binding
Identical Protein Binding
Metal Ion Binding
DNA Replication Origin Binding
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
Cell Proliferation
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
Neural Precursor Cell Proliferation
Pathways
G2/M Checkpoints
Activation of the pre-replicative complex
DNA Replication Pre-Initiation
Regulation of DNA replication
M/G1 Transition
Activation of the pre-replicative complex
Cell Cycle, Mitotic
G1/S Transition
Activation of ATR in response to replication stress
Cell Cycle Checkpoints
Removal of licensing factors from origins
Mitotic G1-G1/S phases
G2/M Checkpoints
Activation of the pre-replicative complex
Activation of the pre-replicative complex
Orc1 removal from chromatin
Assembly of the pre-replicative complex
Activation of ATR in response to replication stress
G1/S Transition
Assembly of the ORC complex at the origin of replication
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
E2F mediated regulation of DNA replication
Synthesis of DNA
DNA Replication Pre-Initiation
Regulation of DNA replication
M/G1 Transition
S Phase
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Orc1 removal from chromatin
E2F-enabled inhibition of pre-replication complex formation
Cell Cycle Checkpoints
Association of licensing factors with the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
32 interactors:
APP
CALCOCO2
CCDC85B
CCND1
CCND3
CDC45
CDC5L
CDC6
CDC7
CDK6
CDKN1A
CDKN2A
CEP70
CEP72
DPPA2
GOLGA2
HAUS1
HOOK2
IKBKG
KRT15
MCM2
MCM3
MCM6
MCM7
NINL
ORC2
ORC3
ORC4
TRIM37
VPRBP
ZBTB43
ZBTB8A
18 interactors:
APP
CCNE2
CDC45
CDC6
CDK4
DBF4
HIST3H3
HIST4H4
MCM10
MCM4
MCM5
MCM7
ORC1
ORC2
ORC4
ORC5
ORC6
TERF2
Entrez ID
55388
23595
HPRD ID
11297
05398
Ensembl ID
ENSG00000065328
ENSG00000135336
Uniprot IDs
Q7L590
Q9UBD5
PDB IDs
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cell Cycle
Cell Cycle Process
DNA Replication Initiation
DNA-dependent DNA Replication
DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
DNA Metabolic Process
Regulation Of Cell Cycle Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Macromolecule Biosynthetic Process
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
DNA Duplex Unwinding
DNA Geometric Change
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
DNA Unwinding Involved In DNA Replication
Cellular Nitrogen Compound Metabolic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Mitotic Cell Cycle
Cell Division
Biosynthetic Process
DNA Conformation Change
Double-strand Break Repair Via Break-induced Replication
Nitrogen Compound Metabolic Process
Organelle Organization
Chromosome Organization
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To DNA Damage Stimulus
Cell Cycle Checkpoint
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Phosphorylation
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Replication
DNA Replication Initiation
Mitotic Cell Cycle
DNA Metabolic Process
DNA-dependent DNA Replication
Mitotic Cell Cycle Process
Cell Cycle
Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Strand Elongation Involved In DNA Replication
Cellular Macromolecule Biosynthetic Process
DNA Strand Elongation
Macromolecule Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Cellular Metabolic Process
DNA Duplex Unwinding
Biosynthetic Process
DNA Geometric Change
Chromosome Organization
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Conformation Change
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Telomere Maintenance
DNA Replication Checkpoint
DNA Unwinding Involved In DNA Replication
Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Metabolic Process
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle G1/S Phase Transition
Organelle Organization
Regulation Of Mitotic Cell Cycle
Cell Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of DNA Replication
Cell Cycle Checkpoint
Tagcloud
?
cerevisiae
deadpan
delay
discs
driver
drosophila
enhancer
eye
eyes
gal4
gmr
imaginal
interference
involvement
klingon
knockdown
lacz
maintenance
mini
monitor
morphology
ommatidia
phases
photoreceptor
r7
replication
rough
surprisingly
Tagcloud (Difference)
?
cerevisiae
deadpan
delay
discs
driver
drosophila
enhancer
eye
eyes
gal4
gmr
imaginal
interference
involvement
klingon
knockdown
lacz
maintenance
mini
monitor
morphology
ommatidia
phases
photoreceptor
r7
replication
rough
surprisingly
Tagcloud (Intersection)
?