MCM10 and CDC6

Number of citations of the paper that reports this interaction (PubMedID 15232106)
0

Data Source:
HPRD (in vitro)

		MCM10	CDC6
Description		minichromosome maintenance 10 replication initiation factor	cell division cycle 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle
	Molecular Function	DNA Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Protein Serine/threonine Kinase Binding
	Biological Process	DNA Replication DNA Replication Initiation DNA Damage Response Cell Population Proliferation	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases
GWAS		Nicotine dependence symptom count ( 25555482) Survival time in esophageal squamous cell carcinoma ( 34185429)	Asthma ( 31619474)
Interacting Genes		37 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A	40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FAM13A-AS1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PLK1 PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBC UBE2K UBR1
Entrez ID		55388	990
HPRD ID		11297	04022
Ensembl ID		ENSG00000065328	ENSG00000094804
Uniprot IDs		Q7L590	Q99741
PDB IDs			2CCH 2CCI 4I5L 4I5N 8HT7 8RWV 8S0E
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Origin Binding CMG Complex Regulation Of DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region MCM Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Stress DNA Damage Response Origin Recognition Complex Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle DNA Recombination G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Nucleus Regulation Of Cell Cycle Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding Cell Division Cyclin D1-CDK6 Complex Cyclin D3-CDK6 Complex DNA Replication Preinitiation Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Single-stranded DNA Helicase Activity Centrosome Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Helicase Activity DNA Repair Protein Serine/threonine Kinase Binding Mitotic Cell Cycle Phase Transition Cytoplasm Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cell Cycle Process Cell Cycle Phase Transition	DNA Replication Initiation DNA Replication Regulation Of DNA Replication Nucleoplasm DNA Metabolic Process DNA Replication Origin Binding Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Cell Cycle G2/M Phase Transition Protein Modification Process Positive Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Primary Metabolic Process Chromosome Positive Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fibroblast Proliferation Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Nucleolus
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