MCM10 and UBAC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MCM10	UBAC1
Description		minichromosome maintenance 10 replication initiation factor	UBA domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	DNA Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Proteasome Binding
	Biological Process	DNA Replication DNA Replication Initiation DNA Damage Response Cell Population Proliferation	Protein Ubiquitination Protein Maturation
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Nicotine dependence symptom count ( 25555482) Survival time in esophageal squamous cell carcinoma ( 34185429)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		37 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A	37 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A FAS HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MECOM MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBC UBQLN2 WWP2 ZDHHC17 ZG16B
Entrez ID		55388	10422
HPRD ID		11297	12170
Ensembl ID		ENSG00000065328	ENSG00000130560
Uniprot IDs		Q7L590	A0A140VK64 Q9BSL1
PDB IDs			2DAI
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Origin Binding CMG Complex Regulation Of DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region MCM Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Stress DNA Damage Response Origin Recognition Complex Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle DNA Recombination G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Nucleus Regulation Of Cell Cycle Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding Cell Division Cyclin D1-CDK6 Complex Cyclin D3-CDK6 Complex DNA Replication Preinitiation Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Single-stranded DNA Helicase Activity Centrosome Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Helicase Activity DNA Repair Protein Serine/threonine Kinase Binding Mitotic Cell Cycle Phase Transition Cytoplasm Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cell Cycle Process Cell Cycle Phase Transition	Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Collateral Sprouting In Absence Of Injury Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Positive Regulation Of Aggrephagy Transferase Activity Post-translational Protein Modification Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Catabolic Process Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Protein Targeting To Vacuole Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Identical Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Signal Transduction Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Segment Specification Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Regulation Of Developmental Growth Catabolic Process Receptor Catabolic Process
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