NINL and ZFHX3

Number of citations: 0 (PubMedID 16189514)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		NINL	ZFHX3
Name		ninein like	zinc finger homeobox 3
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding
	Biological Process	Microtubule Anchoring At Centrosome	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Circadian Regulation Of Gene Expression Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Locomotor Rhythm
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	RUNX3 regulates CDKN1A transcription
GWAS		Brain morphology (MOSTest) ( 32665545 ) Macular thickness ( 30535121 ) Telomere length ( 30185882 ) Urate levels ( 31578528 )	Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818 19597491 19597492 22544366 ) Behavioural changes in frontotemporal lobe dementia ( 29724592 ) Body mass index ( 29273807 28892062 ) Brain morphology (MOSTest) ( 32665545 ) Cardioembolic stroke (CCS and TOAST classification) ( 32047268 ) Cardioembolic stroke (CCS or TOAST classification) ( 32047268 ) Cardioembolic stroke (CCSc classification) ( 32047268 ) Cardioembolic stroke (CCSp classification) ( 32047268 ) Cardioembolic stroke (TOAST classification) ( 32047268 ) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697 ) Chronotype ( 30696823 ) Early onset atrial fibrillation ( 28460022 ) Estimated glomerular filtration rate ( 31015462 31152163 31451708 ) General risk tolerance (MTAG) ( 30643258 ) Glucocorticoid-induced osteonecrosis ( 26265699 ) Heel bone mineral density ( 30598549 ) Hypospadias ( 25108383 ) Incident atrial fibrillation ( 28416818 ) Ischemic stroke (cardioembolic) ( 26708676 ) Kawasaki disease ( 19132087 ) LDL cholesterol ( 21347282 ) Lung function (FVC) ( 30061609 ) Metabolite levels ( 22916037 23823483 ) Morning person ( 30696823 ) Nose morphology ( 29921221 ) Number of sexual partners ( 30643258 ) Photic sneeze reflex ( 27182965 ) Prevalent atrial fibrillation ( 28416818 ) Refractive error ( 32231278 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Serum alkaline phosphatase levels ( 33547301 ) Sick sinus syndrome ( 33580673 ) Smoking status (ever vs never smokers) ( 30643258 ) Stroke (ischemic) ( 23041239 ) Type 2 diabetes ( 32499647 )
Interacting Genes		52 interacting genes: AKAP17A APEX2 AURKB CBY2 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA ERBB2 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 PRPF18 PRPF3 RBM41 RCOR3 RGS2 RIBC2 RNF40 SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSC1 TSPYL4 UTP14A YJU2B ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646	36 interacting genes: ALKBH4 AURKA BHLHE40 CEP70 CNOT2 COPS6 CSTPP1 DEUP1 EFHC2 GOLGA2 GOLGA6L9 HIVEP1 KRT31 KRT34 KRT40 LMNB2 MSX2 MTUS2 MYB NINL PIAS3 PIBF1 PICK1 POU2F1 POU6F2 PRPF40A RBM11 SPECC1L TACC1 TLE5 TRIM27 TRIM54 TRIML2 TTC23 USHBP1 ZNF620
Entrez ID		22981	463
HPRD ID		11120	00075
Ensembl ID		ENSG00000101004	ENSG00000140836
Uniprot IDs		Q9Y2I6	Q15911 Q8N2Y6
PDB IDs		Not available	2DA1 2DA2 2DA3
GO Terms Enriched among Interactors		Mitotic Spindle Pole Nucleus Protein Binding Chromosome, Centromeric Region Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Pole Regulation Of Metaphase Plate Congression Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Positive Regulation Of Chromosome Segregation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H4K16 Acetyltransferase Activity Spindle Microtubule Protein Localization To Chromosome Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cytoskeleton Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Negative Regulation Of Cell Cycle Phase Transition Zinc Ion Binding Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation RNA Splicing Centrosome	Cytoskeleton Organization Cytoskeleton Microtubule Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Mitotic Spindle Organization Microtubule Organizing Center Microtubule Cytoskeleton Organization Involved In Mitosis Structural Constituent Of Skin Epidermis Cilium Disassembly Centrosome Spindle Organization Cell Division Intermediate Filament Meiotic Spindle Assembly Intermediate Filament Organization Organelle Disassembly Microtubule Organizing Center Organization SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Meiotic Spindle Organization Spindle Assembly Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process