FASN and YWHAQ

Number of citations of the paper that reports this interaction (PubMedID 15161933)
0

Data Source:
BioGRID (pull down)

		FASN	YWHAQ
Description		fatty acid synthase	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome
	Molecular Function	RNA Binding Catalytic Activity Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity Protein Binding Fatty Acyl-[ACP] Hydrolase Activity Oxidoreductase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Lyase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding
	Biological Process	Osteoblast Differentiation Epithelial Cell Development Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Inflammatory Response Response To Nutrient Lipid Biosynthetic Process Ether Lipid Biosynthetic Process Tissue Development Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Response To Nutrient Levels Host-mediated Perturbation Of Viral Process Fatty-acyl-CoA Biosynthetic Process Response To Caloric Restriction Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription
Pathways		ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs		Cerulenin Orlistat	Phenethyl Isothiocyanate
Diseases
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688) Refractive error ( 32231278)	Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)
Interacting Genes		16 interacting genes: ADIPOQ AKT1 CEBPA CRYAA DUX4 EWSR1 HSP90AA1 LNX1 MTDH NDRG1 PRR12 PTEN RPF1 SNX8 SUMO2 YWHAQ	216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2
Entrez ID		2194	10971
HPRD ID		02567	00886
Ensembl ID		ENSG00000169710	ENSG00000134308
Uniprot IDs		P49327	P27348
PDB IDs		1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA 7MHD 7MHE 8EYI 8EYK 8G7X 8GKC 8VF7 8VG4 8VLE 8VLO 8VLP 8VM0 8VM5 8VM6 8VM7 8VMC 8VMD 9B7Z 9B80 9MJ9	2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Myelin Maintenance Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Fat Cell Differentiation Positive Regulation Of Catabolic Process Nitric-oxide Synthase Regulator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteolysis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Nucleus Regulation Of Gene Expression Response To Heat Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Synapse Maturation Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Proteasomal Protein Catabolic Process Plasma Membrane Organization Response To Decreased Oxygen Levels Programmed Cell Death Response To Tumor Necrosis Factor Cell Death Response To Oxygen Levels Protein Refolding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Peptidyl-serine Phosphorylation Reactive Nitrogen Species Metabolic Process Response To Temperature Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation 14-3-3 Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Brown Fat Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Homodimerization Activity	Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus
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