FASN

Gene Name		fatty acid synthase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Vesicular Exosome
	Molecular Function	Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity Enoyl-[acyl-carrier-protein] Reductase (NADPH, B-specific) Activity Oleoyl-[acyl-carrier-protein] Hydrolase Activity Protein Binding Drug Binding Zinc Ion Binding Myristoyl-[acyl-carrier-protein] Hydrolase Activity Palmitoyl-[acyl-carrier-protein] Hydrolase Activity Protein Homodimerization Activity Poly(A) RNA Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity 3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity NADPH Binding
	Biological Process	Osteoblast Differentiation Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Pantothenate Metabolic Process Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cellular Response To Interleukin-4
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Fatty Acyl-CoA Biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Triglyceride Biosynthesis Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Vitamin B5 (pantothenate) metabolism Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs		Cerulenin Orlistat
Diseases
GWAS
Protein-protein Interactions		4 interactors: EWSR1 NDRG1 PRR12 YWHAQ
Entrez ID		2194
HPRD ID		02567
Ensembl ID		ENSG00000169710
Uniprot IDs		P49327
PDB IDs		1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Spindle Checkpoint Positive Regulation Of Cell Cycle Checkpoint Peripheral Nervous System Myelin Maintenance Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Spindle Checkpoint Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Myelin Maintenance Membrane Organization Mast Cell Activation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Substantia Nigra Development
Tagcloud ?		acc adipose adiposity carboxylase coa conceivable db depot dio distension distortion epidemiologic follicular hypofunction hypothyroidism intrathyroidal lipogenesis ob obese peroxisome proliferator srebp steatosis sterol synthetase systemically thyroid ultrastructural uniformly