FASN and ADIPOQ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FASN	ADIPOQ
Description		fatty acid synthase	adiponectin, C1Q and collagen domain containing
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Cell Surface Extracellular Matrix Protein-containing Complex
	Molecular Function	RNA Binding Catalytic Activity Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity Protein Binding Fatty Acyl-[ACP] Hydrolase Activity Oxidoreductase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Lyase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity	Signaling Receptor Binding Cytokine Activity Hormone Activity Extracellular Matrix Structural Constituent Protein Binding Sialic Acid Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Osteoblast Differentiation Epithelial Cell Development Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Inflammatory Response Response To Nutrient Lipid Biosynthetic Process Ether Lipid Biosynthetic Process Tissue Development Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Response To Nutrient Levels Host-mediated Perturbation Of Viral Process Fatty-acyl-CoA Biosynthetic Process Response To Caloric Restriction Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Beta-oxidation Response To Nutrient Circadian Rhythm Response To Xenobiotic Stimulus Response To Bacterium Response To Sucrose Response To Glucose Positive Regulation Of Signal Transduction Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Response To Activity Fatty Acid Oxidation Negative Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Response To Nutrient Levels Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Positive Regulation Of Myeloid Cell Apoptotic Process Adiponectin-activated Signaling Pathway Negative Regulation Of Heterotypic Cell-cell Adhesion Low-density Lipoprotein Particle Clearance Response To Tumor Necrosis Factor Glucose Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAP Kinase Activity Response To Ethanol Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of DNA-templated Transcription Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of D-glucose Import Negative Regulation Of Hormone Secretion Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Negative Regulation Of Synaptic Transmission Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Cholesterol Import Negative Regulation Of ERK1 And ERK2 Cascade Response To Linoleic Acid Detection Of Oxidative Stress Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Response To Epinephrine Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Intracellular Protein Transport Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Receptor Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Renal Albumin Absorption Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Cerulenin Orlistat
Diseases			Adiponectin deficiency
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688) Refractive error ( 32231278)	Activated partial thromboplastin time ( 22703881) Adiponectin levels ( 19165155 20011104 20018283 20876611 21700879 22479202 24105470 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Adiponectin levels in pregnancy ( 28317342) Copper levels ( 26025379)
Interacting Genes		16 interacting genes: ADIPOQ AKT1 CEBPA CRYAA DUX4 EWSR1 HSP90AA1 LNX1 MTDH NDRG1 PRR12 PTEN RPF1 SNX8 SUMO2 YWHAQ	62 interacting genes: ADIPOR2 AMIGO1 AQP6 ASGR2 BCL2L13 BIK BNIP3L BSND BTNL9 CAMLG CCDC107 CD200R1 CD79A CDH13 CLDN9 CLEC10A CLEC2D CNR2 COQ9 CPLX4 CREB3L1 CYBC1 ERGIC3 ERP29 FAM209A FASN FCGR1A FKBP7 FNDC9 GPR152 GPR42 HSD17B11 IFNGR2 KASH5 KCNK5 KEL MFF MFSD6 MRM1 MS4A3 MUC1 NEMP1 PEX12 PROKR2 PVR SCN3B SGTA SGTB SIGLEC12 SLC16A2 SLC22A23 SLC35E3 SLC35H1 SLC71A2 SYAP1 SYNE4 TMEM179B TMEM237 TMEM35A TMPRSS2 TNFSF14 TRIM35
Entrez ID		2194	9370
HPRD ID		02567	05671
Ensembl ID		ENSG00000169710	ENSG00000181092
Uniprot IDs		P49327	A8K660 B2R773 Q15848
PDB IDs		1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA 7MHD 7MHE 8EYI 8EYK 8G7X 8GKC 8VF7 8VG4 8VLE 8VLO 8VLP 8VM0 8VM5 8VM6 8VM7 8VMC 8VMD 9B7Z 9B80 9MJ9	4DOU 6U66 6U6N
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Myelin Maintenance Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Fat Cell Differentiation Positive Regulation Of Catabolic Process Nitric-oxide Synthase Regulator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteolysis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Nucleus Regulation Of Gene Expression Response To Heat Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Synapse Maturation Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Proteasomal Protein Catabolic Process Plasma Membrane Organization Response To Decreased Oxygen Levels Programmed Cell Death Response To Tumor Necrosis Factor Cell Death Response To Oxygen Levels Protein Refolding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Peptidyl-serine Phosphorylation Reactive Nitrogen Species Metabolic Process Response To Temperature Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation 14-3-3 Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Brown Fat Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Homodimerization Activity	Membrane Protein Binding Plasma Membrane TRC Complex External Side Of Plasma Membrane Adiponectin Binding
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