ALDH3A1 and POT1

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		ALDH3A1	POT1
Gene Name		aldehyde dehydrogenase 3 family, member A1	protection of telomeres 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Alcohol Dehydrogenase (NADP+) Activity	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding
	Biological Process	Response To Hypoxia Cellular Aldehyde Metabolic Process Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Drug Response To Glucocorticoid Response To CAMP Oxidation-reduction Process	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs		NADH Nicotinamide-Adenine-Dinucleotide
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CYHR1 POT1 SRF	166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790
Entrez ID		218	25913
HPRD ID		00004	07572
Ensembl ID		ENSG00000108602	ENSG00000128513
Uniprot IDs		P30838 Q6PKA6	A8MTK3 Q5MJ33 Q9NUX5
PDB IDs		3SZA 3SZB	1XJV 3KJO 3KJP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Strand Elongation Contractile Actin Filament Bundle Assembly Negative Regulation Of Beta-amyloid Clearance Telomere Formation Via Telomerase Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Telomere Capping Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Beta-amyloid Clearance Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Transcription By Glucose Tangential Migration From The Subventricular Zone To The Olfactory Bulb Carbon Catabolite Regulation Of Transcription Dorsal Aorta Morphogenesis Dorsal Aorta Development Negative Regulation Of Telomerase Activity Positive Thymic T Cell Selection Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Primitive Streak Formation MRNA Transcription From RNA Polymerase II Promoter Hematopoietic Stem Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Stress Fiber Assembly Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Regulation Of Telomerase Activity MRNA Transcription Positive Regulation Of Transcription Via Serum Response Element Binding Coronary Vasculature Development Cardioblast Differentiation Megakaryocyte Development Heart Trabecula Formation Long Term Synaptic Depression Eyelid Development In Camera-type Eye Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of Smooth Muscle Cell Differentiation Angiogenesis Involved In Wound Healing Vascular Smooth Muscle Cell Differentiation Regulation Of Telomere Maintenance Regulation Of Water Loss Via Skin Positive Regulation Of DNA Biosynthetic Process Epithelial Structure Maintenance	Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process
Tagcloud ?		a3 aldehyde bioinformatics chose classify conjunctiva conjunctival david differentially dimeric electrospray excised finnigan isomerase ltq nadp ontology pdia3 peroxiredoxin prdx2 preferring presumed proteomex proteomic pterygia pterygial pterygium thermo workstation	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip
Tagcloud (Difference) ?		a3 aldehyde bioinformatics chose classify conjunctiva conjunctival david differentially dimeric electrospray excised finnigan isomerase ltq nadp ontology pdia3 peroxiredoxin prdx2 preferring presumed proteomex proteomic pterygia pterygial pterygium thermo workstation	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip
Tagcloud (Intersection) ?