ALDH3A1 and FBXL12

Number of citations: 0 (PubMedID 26124079)
Data Source: BioGRID (enzymatic study)

		ALDH3A1	FBXL12
Name		aldehyde dehydrogenase 3 family member A1	F-box and leucine rich repeat protein 12
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane	Ubiquitin Ligase Complex Cytoplasm Cytosol
	Molecular Function	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NAD+) Activity	Protein Binding
	Biological Process	Aldehyde Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		Phase I - Functionalization of compounds	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		NADH	None
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood protein levels ( 30072576 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Refractive astigmatism ( 30306274 )	Pursuit maintenance gain ( 29064472 )
Novel Interactors		None recorded	5 novel interactors: MARCHF2 SHFL ZNF44 ZNF562 ZNF823
Interacting Genes		5 interacting genes: FBXL12 FKBP6 POT1 SRF ZFTRAF1	19 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FBF1 FXYD3 GEMIN4 LNX1 MAST1 PSEN1 PSEN2 PSME3 RNF32 SMAD1 TGFBR1 UBE2D3
Entrez ID		218	54850
HPRD ID		00004	12363
Ensembl ID		ENSG00000108602	ENSG00000127452
Uniprot IDs		I3L3I9 P30838 Q6PKA6	Q9NXK8
PDB IDs		3SZA 3SZB 4H80 4L1O 4L2O 8BB8	Not available
GO Terms Enriched among Interactors		Serum Response Element Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Trachea Cartilage Development Bronchus Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Positive Regulation Of Transcription By Glucose Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Dorsal Aorta Morphogenesis Primary MiRNA Binding Tangential Migration From The Subventricular Zone To The Olfactory Bulb Single-stranded Telomeric DNA Binding Telomerase Inhibitor Activity Nuclear Telomere Cap Complex Shelterin Complex Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding Establishment Of Protein Localization To Telomere Negative Regulation Of Amyloid-beta Clearance Primitive Streak Formation Cardiac Muscle Cell Myoblast Differentiation FK506 Binding Telomeric Loop Disassembly G-rich Strand Telomeric DNA Binding Skin Morphogenesis Positive Thymic T Cell Selection Cardioblast Differentiation Transposable Element Silencing By PiRNA-mediated DNA Methylation Telomere Capping Heart Trabecula Formation Eyelid Development In Camera-type Eye Positive T Cell Selection Cardiac Myofibril Assembly Long-term Synaptic Depression Regulation Of DNA Strand Elongation Face Development Angiogenesis Involved In Wound Healing Trophectodermal Cell Differentiation Regulation Of Amyloid-beta Clearance Platelet Formation Contractile Actin Filament Bundle Assembly	Amyloid Precursor Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Regulation Of Amyloid Fibril Formation I-SMAD Binding Amyloid Precursor Protein Catabolic Process