ALDH3A1

Name	aldehyde dehydrogenase 3 family member A1
Structure
Interactors	5 interactors: FBXL12 FKBP6 POT1 SRF ZFTRAF1
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane
	Molecular Function	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NAD+) Activity
	Biological Process	Aldehyde Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process
Pathways	Phase I - Functionalization of compounds
Drugs	NADH
GWAS	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood protein levels ( 30072576 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Refractive astigmatism ( 30306274 )
Entrez ID	218
HPRD ID	00004
Ensembl ID	ENSG00000108602
Uniprot IDs	I3L3I9 P30838 Q6PKA6
PDB IDs	3SZA 3SZB 4H80 4L1O 4L2O 8BB8
GO Terms Enriched among Interactors ?	Serum Response Element Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Trachea Cartilage Development Bronchus Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Positive Regulation Of Transcription By Glucose Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Dorsal Aorta Morphogenesis Primary MiRNA Binding Tangential Migration From The Subventricular Zone To The Olfactory Bulb Single-stranded Telomeric DNA Binding Telomerase Inhibitor Activity Nuclear Telomere Cap Complex Shelterin Complex Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding Establishment Of Protein Localization To Telomere Negative Regulation Of Amyloid-beta Clearance Primitive Streak Formation Cardiac Muscle Cell Myoblast Differentiation FK506 Binding Telomeric Loop Disassembly G-rich Strand Telomeric DNA Binding Skin Morphogenesis Positive Thymic T Cell Selection Cardioblast Differentiation Transposable Element Silencing By PiRNA-mediated DNA Methylation Telomere Capping Heart Trabecula Formation Eyelid Development In Camera-type Eye Positive T Cell Selection Cardiac Myofibril Assembly Long-term Synaptic Depression Regulation Of DNA Strand Elongation Face Development Angiogenesis Involved In Wound Healing Trophectodermal Cell Differentiation Regulation Of Amyloid-beta Clearance Platelet Formation Contractile Actin Filament Bundle Assembly