EWSR1 and ITCH

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		EWSR1	ITCH
Gene Name		EWS RNA-binding protein 1	itchy E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Ribonucleoprotein Complex Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Regulation Of Cell Growth Positive Regulation Of T Cell Anergy Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Inflammatory Response Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOD1/2 Signaling Pathway Signaling by NOTCH1 Hedgehog 'on' state Signaling by NOTCH1 in Cancer Class I MHC mediated antigen processing & presentation FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Downregulation of ERBB4 signaling Signaling by NOTCH Signaling by ERBB4 Activated NOTCH1 Transmits Signal to the Nucleus RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by Hedgehog Degradation of GLI1 by the proteasome Adaptive Immune System
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	80 interactors: ARID1A ARRB2 ARRDC1 ARRDC3 ATN1 BECN1 CBL CBLC CDC34 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DTX1 DTX3L DVL2 ERBB4 EWSR1 FYN GNAI2 HNRNPL HNRNPUL1 JUN LAPTM5 LATS1 LITAF MAP2K4 MAPK8 MLANA N4BP1 NDFIP2 NEDD9 NFE2 NOTCH1 NUDT21 NUMB PABPC1 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA RIPK1 RNF11 RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL2 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SNX9 SPG20 STAM2 TP73 TRPC4 TRPV1 TRPV4 TXNIP UBAP2 UBAP2L UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 URI1 WBP2
Entrez ID		2130	83737
HPRD ID		00592	07565
Ensembl ID		ENSG00000182944	ENSG00000078747
Uniprot IDs		Q01844	Q96J02
PDB IDs		2CPE	2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Protein Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Protein K48-linked Ubiquitination Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Protein Polyubiquitination Regulation Of Signaling Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nucleosome Disassembly TRIF-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Protein Catabolic Process Regulation Of Cellular Component Organization DNA-templated Transcription, Initiation Cell Death Death MRNA Splicing, Via Spliceosome
Tagcloud ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week
Tagcloud (Difference) ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week
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