EWSR1 and POU4F1

Number of citations of the paper that reports this interaction (PMID 12432261)
5

Data Source:
HPRD (two hybrid)

		EWSR1	POU4F1
Gene Name		EWS RNA-binding protein 1	POU class 4 homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane	Nuclear Chromatin Neuron Projection
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Suckling Behavior Ventricular Compact Myocardium Morphogenesis Transcription From RNA Polymerase II Promoter Axonogenesis Synapse Assembly Mesoderm Development Cell Migration In Hindbrain Trigeminal Nerve Development Central Nervous System Neuron Differentiation Habenula Development Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Sensory System Development Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Proprioception Involved In Equilibrioception Innervation
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729)	Total ventricular volume ( 21116278)
Protein-Protein Interactions		159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	3 interactors: ESR1 EWSR1 RIT2
Entrez ID		2130	5457
HPRD ID		00592	03379
Ensembl ID		ENSG00000182944	ENSG00000152192
Uniprot IDs		Q01844	Q01851
PDB IDs		2CPE
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death	Prostate Epithelial Cord Elongation Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Vagina Development Uterus Development Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Prostate Gland Growth Cellular Response To Estradiol Stimulus Branching Involved In Prostate Gland Morphogenesis Mammary Gland Epithelial Cell Proliferation Female Genitalia Development Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium Cellular Response To Estrogen Stimulus Axis Elongation Androgen Metabolic Process Prostate Gland Epithelium Morphogenesis Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Prostate Gland Morphogenesis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Mammary Gland Alveolus Development Mammary Gland Lobule Development Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Genitalia Development Positive Regulation Of Phospholipase C Activity Regulation Of Nitric Oxide Biosynthetic Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Mammary Gland Duct Morphogenesis Positive Regulation Of Fibroblast Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Morphogenesis Of A Branching Structure Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Oxidoreductase Activity Maternal Process Involved In Female Pregnancy Mammary Gland Morphogenesis Regulation Of Phospholipase Activity Epithelial Cell Proliferation
Tagcloud ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	3a 3b abrogate brn cardiomyocyte cardiomyocytes fate generalised h9c2 infarct injured ischaemia ischaemic localisation localised minimise myoblasts myocardium myocyte necroptosis noxa nrvm operates puma reoxygenation rip uninjured zone
Tagcloud (Difference) ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	3a 3b abrogate brn cardiomyocyte cardiomyocytes fate generalised h9c2 infarct injured ischaemia ischaemic localisation localised minimise myoblasts myocardium myocyte necroptosis noxa nrvm operates puma reoxygenation rip uninjured zone
Tagcloud (Intersection) ?