EWSR1 and NPPB

Number of citations: 0 (PubMedID 16189514)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		EWSR1	NPPB
Name		EWS RNA binding protein 1	natriuretic peptide B
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cajal Body Membrane	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex
	Molecular Function	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding
	Biological Process	Regulation Of DNA-templated Transcription	System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Killing Of Cells Of Another Organism Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Regulation Of Vascular Permeability Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Drugs		None	Carvedilol Oxymetholone
Diseases		Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue	None
GWAS		Breast cancer ( 23535729 ) Pancreatic cancer ( 25086665 ) Platelet count ( 27863252 ) Platelet distribution width ( 32888494 )	B-type natriuretic peptide levels ( 25561047 29237677 ) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677 ) Blood pressure ( 21909110 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Diastolic blood pressure ( 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Hip index ( 34021172 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) N-terminal pro B-type natriuretic peptide levels ( 29237677 ) NT-proBNP levels in acute coronary syndrome ( 26908625 ) Pulse pressure ( 30578418 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure ( 28739976 27618452 27618447 19430483 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Tuberculosis ( 29036319 )
Interacting Genes		164 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BRME1 BTK C11orf16 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CEBPA CETP CFAP298 CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 OGT PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B PTP4A2 RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	13 interacting genes: CYSRT1 EWSR1 GEMIN4 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3 SERTAD3
Entrez ID		2130	4879
HPRD ID		00592	08974
Ensembl ID		ENSG00000182944	ENSG00000120937
Uniprot IDs		A0A0D9SFL3 Q01844	P16860
PDB IDs		2CPE	1YK1 3N56
GO Terms Enriched among Interactors		Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Transcription Regulator Complex Chromatin Remodeling MRNA Metabolic Process Brahma Complex NpBAF Complex RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Chromatin Single-stranded DNA Binding Protein-containing Complex Negative Regulation Of DNA-templated Transcription Cardiac Conduction System Development Chromatin Binding Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Nucleosome Disassembly TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process	Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Keratin Filament Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase I Neuronal Action Potential Ribose Phosphate Biosynthetic Process Intermediate Filament Regulation Of Cell Growth Negative Regulation Of Cell Growth Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process G Protein-coupled Peptide Receptor Activity Regulation Of Myotube Differentiation Regulation Of Transcription By RNA Polymerase I Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Blood Circulation Nucleotide Biosynthetic Process ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Blood Vessel Remodeling D-glucose:proton Symporter Activity Galactose:proton Symporter Activity Regulation Of Glycolytic Process Negative Regulation Of Growth Purine-containing Compound Biosynthetic Process Cajal Body Regulation Of Locomotor Rhythm Regulation Of Carbohydrate Catabolic Process TFIIIC-class Transcription Factor Complex Binding Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Sucrose Transport Sucrose:proton Symporter Activity Nucleobase-containing Small Molecule Metabolic Process Regulation Of ATP Metabolic Process