Wiki-Pi
About
Search
People
Updates
Search
EWSR1 and TRAF3
Number of citations of the paper that reports this interaction (PubMedID
35271311
)
106
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
EWSR1
TRAF3
Description
EWS RNA binding protein 1
TNF receptor associated factor 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Plasma Membrane
Cajal Body
Membrane
Ubiquitin Ligase Complex
Cytoplasm
Mitochondrion
Endosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Membrane
CD40 Receptor Complex
Serine/threonine Protein Kinase Complex
Molecular Function
Nucleic Acid Binding
Transcription Coregulator Activity
RNA Binding
Protein Binding
Calmodulin Binding
Zinc Ion Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Regulation Of DNA-templated Transcription
Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
Immune System Process
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Toll Signaling Pathway
MRNA Transcription
Regulation Of Proteolysis
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Regulation Of Interferon-beta Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Defense Response To Virus
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Antiviral Innate Immune Response
Pathways
TRAF3 deficiency - HSE
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
Extraskeletal myxoid chondrosarcoma
Myxoid liposarcoma
Ewing's sarcoma
Clear cell sarcoma of soft tissue
GWAS
Breast cancer (
23535729
)
Pancreatic cancer (
25086665
)
Platelet count (
27863252
)
Platelet distribution width (
32888494
)
Adult body size (
32376654
)
Age at first birth (
34211149
)
Age at first sexual intercourse (
34211149
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Asthma (
32296059
)
Asthma (childhood onset) (
30929738
)
Body mass index (
29273807
25673413
)
Body size at age 10 (
32376654
)
Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) (
19023125
)
Composite immunoglobulin trait (IgA x IgG/IgM) (
28628107
)
Eczema (
31361310
)
Gallstone disease (
30692554
)
Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment (
33608531
)
HDL cholesterol levels (
32203549
)
Immunoglobulin measurement (zinc sulfate turbidity test) (
29403010
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Major depressive disorder (MTAG) (
33479212
)
Monocyte count (
32888494
)
Multiple sclerosis (
24076602
31604244
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Red blood cell count (
32888494
)
Serum total protein levels (
29403010
)
Systemic lupus erythematosus (
33536424
28714469
)
Type 2 diabetes (
32499647
)
Interacting Genes
164 interacting genes:
ACTL6A
AGT
ANXA11
ARID1A
ATN1
ATPAF2
ATXN3
BAD
BARD1
BLZF1
BNIP3L
BRME1
BTK
C11orf16
CALM1
CCDC7
CCDC91
CD177
CDK12
CEACAM5
CEBPA
CETP
CFAP298
CFDP1
CHERP
CNST
CPSF6
CPSF7
CREBBP
CUEDC2
CXADR
DFFA
DMRTB1
DNAJB3
DYNLL2
E2F8
ECD
ELAVL3
ELAVL4
ELK1
EPAS1
ERCC5
FAM131C
FASN
FLI1
FXR2
GNPDA1
GPBP1L1
H2BC15
HBP1
HDAC3
HERPUD1
HLTF
HMGA1
HMGN4
HNRNPUL1
HSPA2
IRF3
ITCH
ITGB5
JUN
KCNMB1
KEL
KHDRBS2
KRR1
KXD1
LILRA3
MAGEA11
MAPK1IP1L
MATK
MDFI
MNS1
MRPS18B
MSC
MTCP1
MTMR9
MVK
MYL6
MYO1F
MYOZ2
NBPF3
NDRG1
NDUFB1
NDUFV1
NINL
NLE1
NONO
NPPB
NSUN4
NTNG2
OGT
PCBP1
PDHX
PEF1
PGLS
PLSCR1
POLR2G
POLR3A
POU4F1
POU5F1
PRKCA
PRMT1
PRR13
PRRC2A
PRTFDC1
PRUNE2
PTK2B
PTP4A2
RAB37
RAD23A
RALYL
RASL11B
RBPMS
RFX3
RHOXF2
RMND5B
RNF183
RPL31
RPS15A
SALL2
SCMH1
SEC24A
SEC24D
SELENOI
SERP2
SF1
SF3B4
SLC1A1
SLC22A24
SMAD1
SMAD4
SMARCC1
SMARCC2
SNRPC
SSBP2
SSBP3
SUPT4H1
SUV39H2
TAF1
TFG
TMSB4Y
TONSL
TPGS2
TRAF1
TRAF2
TRAF3
TRIM37
TRIM5
TRPV5
TSPAN3
TULP2
USP7
VPS72
WBP4
WDR37
WWP1
WWP2
YWHAG
YY1AP1
ZBTB1
ZDHHC3
ZNF165
ZNF184
ZNF383
86 interacting genes:
ABCC1
ALPL
APOBEC3C
ASCC1
AZI2
BEX3
BIVM
C10orf62
CASP3
CCDC13
CCDC184
CD27
CD40
CDC37
CELF2
DAXX
EDA2R
EDAR
EWSR1
FAS
GMEB2
GRIN1
GRIN2D
HEMGN
HNRNPC
IFT25
IL15
IP6K3
IRF1
LNX1
LTBR
MAP2K1
MAP3K14
MAP3K7
MAVS
MFF
NEDD4L
NTAQ1
NUP62
OTUD5
PDLIM7
PDZD4
PIAS2
POM121
PSMB8
PTPN6
RAD23A
RIPK1
RIPPLY1
RNF216
RNF4
RRAS2
SAR1A
SHANK3
SRC
STK38
TANK
TBK1
TDP2
TICAM1
TNFRSF11A
TNFRSF12A
TNFRSF13C
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TRADD
TRAF2
TRAF3IP1
TRAF3IP2
TRAF3IP3
TRAF5
TRIM24
TRIM37
UBE2I
USP7
ZBP1
ZBTB49
ZMYND11
ZSCAN4
Entrez ID
2130
7187
HPRD ID
00592
03539
Ensembl ID
ENSG00000182944
ENSG00000131323
Uniprot IDs
A0A0D9SFL3
Q01844
A6NHG8
Q13114
PDB IDs
2CPE
1FLK
1FLL
1KZZ
1L0A
1RF3
1ZMS
2ECY
2GKW
8T5P
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Nucleus
Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
RNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
DNA-templated Transcription
Transcription Regulator Complex
Chromatin Remodeling
MRNA Metabolic Process
Brahma Complex
NpBAF Complex
RNA Metabolic Process
Regulation Of Gene Expression
Nucleic Acid Binding
Chromatin
Single-stranded DNA Binding
Protein-containing Complex
Negative Regulation Of DNA-templated Transcription
Cardiac Conduction System Development
Chromatin Binding
Negative Regulation Of RNA Biosynthetic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Protein Binding
MRNA Transcription
Negative Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Nucleosome Disassembly
TORC1 Signaling
Negative Regulation Of Macromolecule Biosynthetic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor Receptor Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway
Apoptotic Process
Cell Death
Programmed Cell Death
Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Defense Response
Tumor Necrosis Factor Receptor Superfamily Complex
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Type I Interferon Production
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Defense Response
Signaling Receptor Activity
Positive Regulation Of Gene Expression
Death-inducing Signaling Complex
Defense Response To Virus
Regulation Of Cell Communication
Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Mononuclear Cell Proliferation
Regulation Of JNK Cascade
Cellular Response To Mechanical Stimulus
Regulation Of Gene Expression
Intracellular Signal Transduction
Response To Stress
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
CD40 Signaling Pathway
Regulation Of Leukocyte Proliferation
Regulation Of Immune System Process
Regulation Of MAPK Cascade
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cytokine Production
Immune Response
Response To External Biotic Stimulus
Positive Regulation Of Type I Interferon Production
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?