EWSR1 and ZNF165

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		EWSR1	ZNF165
Description		EWS RNA binding protein 1	zinc finger protein 165
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cajal Body Membrane	Nucleus
	Molecular Function	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue
GWAS		Breast cancer ( 23535729) Pancreatic cancer ( 25086665) Platelet count ( 27863252) Platelet distribution width ( 32888494)	Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31451708) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Hepcidin/ferritin ratio ( 27846281) LDL cholesterol levels ( 32203549) Lung function (FEV1/FVC) ( 30175238) Moderate to vigorous physical activity levels ( 29899525) Refractive error ( 32231278) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		164 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BRME1 BTK C11orf16 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CEBPA CETP CFAP298 CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 OGT PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B PTP4A2 RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	46 interacting genes: AHCYL1 CARD10 CCDC125 CCDC85B CEP70 DVL2 DVL3 ELOA2 EMD EWSR1 FAM124A GOLGA6L9 GPATCH2L HOMEZ IL16 KAT7 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-12 MAB21L3 MID2 NTAQ1 PDLIM7 PICK1 PLEKHF2 PPL RNPS1 SCAND1 SUV39H1 TRIM41 YJU2B ZKSCAN8 ZNF24 ZNF250 ZNF263 ZNF417 ZNF446 ZNF572 ZNF668 ZNF774 ZNF837
Entrez ID		2130	7718
HPRD ID		00592	02903
Ensembl ID		ENSG00000182944	ENSG00000197279
Uniprot IDs		A0A0D9SFL3 Q01844	P49910 Q53Z40
PDB IDs		2CPE
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Transcription Regulator Complex Chromatin Remodeling MRNA Metabolic Process Brahma Complex NpBAF Complex RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Chromatin Single-stranded DNA Binding Protein-containing Complex Negative Regulation Of DNA-templated Transcription Cardiac Conduction System Development Chromatin Binding Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Nucleosome Disassembly TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process	Keratin Filament Intermediate Filament Regulation Of RNA Metabolic Process Zinc Ion Binding Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Neuron Projection Arborization Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Neuron Projection Arborization
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