EWSR1 and CETP

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EWSR1	CETP
Gene Name		EWS RNA-binding protein 1	cholesteryl ester transfer protein, plasma
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane	Extracellular Region Extracellular Space Vesicle High-density Lipoprotein Particle Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding	Lipid Transporter Activity Phospholipid Transporter Activity Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Triglyceride Binding Phosphatidylcholine Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Triglyceride Metabolic Process Lipid Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Efflux Phospholipid Transport Cholesterol Transport Triglyceride Transport Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Small Molecule Metabolic Process Phosphatidylcholine Metabolic Process Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis
Pathways			Lipoprotein metabolism HDL-mediated lipid transport LDL-mediated lipid transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport Orphan transporters
Drugs
Diseases
GWAS		Breast cancer ( 23535729)	Age-related macular degeneration ( 20385819 23455636 21665990) Biochemical measures ( 19260141) Cardiovascular disease risk factors ( 21943158 20838585) Cholesterol ( 20066028) Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 23726366 20031538 19359809 20031564 21909109 18193043 18193044 20864672 19060906 23505323 19060910 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) LDL cholesterol ( 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 22916037) Triglycerides ( 17463246 20686565) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	5 interactors: APOA1 ARPC3 EWSR1 LPL PRKACG
Entrez ID		2130	1071
HPRD ID		00592	00325
Ensembl ID		ENSG00000182944	ENSG00000087237
Uniprot IDs		Q01844	P11597
PDB IDs		2CPE	2OBD 4EWS 4F2A
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death	Triglyceride Catabolic Process Acylglycerol Catabolic Process Plasma Lipoprotein Particle Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Glycerolipid Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Triglyceride Metabolic Process Phototransduction Neutral Lipid Metabolic Process Detection Of Light Stimulus Negative Regulation Of Cell Adhesion Molecule Production Lipid Homeostasis Isoprenoid Metabolic Process Cellular Lipid Catabolic Process Negative Regulation Of Interleukin-1 Beta Secretion Chemical Homeostasis Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Chylomicron Remodeling Cellular Lipid Metabolic Process Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Interleukin-1 Secretion Lipid Catabolic Process High-density Lipoprotein Particle Clearance Positive Regulation Of Sequestering Of Triglyceride Protein Oxidation Lipid Metabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Cellular Component Biogenesis Very-low-density Lipoprotein Particle Remodeling Homeostatic Process Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Response To Light Stimulus Response To Stress Regulation Of Actin Cytoskeleton Organization Regulation Of Cholesterol Esterification
Tagcloud ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	allele allelic b1 b1b1 b2b2 carriers causal causally chd cholesteryl circulating duplicate embase ester genotype genotypic instrument marginally mendelian mug probabilities publication pubmed qualified randomization rs708272 searched unresolved weighted
Tagcloud (Difference) ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	allele allelic b1 b1b1 b2b2 carriers causal causally chd cholesteryl circulating duplicate embase ester genotype genotypic instrument marginally mendelian mug probabilities publication pubmed qualified randomization rs708272 searched unresolved weighted
Tagcloud (Intersection) ?