EWSR1 and PDHX

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EWSR1	PDHX
Gene Name		EWS RNA-binding protein 1	pyruvate dehydrogenase complex, component X
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane	Mitochondrial Matrix
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding	Transferase Activity, Transferring Acyl Groups
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	8 interactors: ACTN1 AGTRAP DLAT DLD EP300 EWSR1 PDHB PDK2
Entrez ID		2130	8050
HPRD ID		00592	02002
Ensembl ID		ENSG00000182944	ENSG00000110435
Uniprot IDs		Q01844	E9PB14 O00330
PDB IDs		2CPE	1ZY8 2DNC 2F5Z 2F60
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Respiration Monocarboxylic Acid Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Metabolic Process Generation Of Precursor Metabolites And Energy Organic Acid Metabolic Process Histone H2B Acetylation Signal Transduction By P53 Class Mediator Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Phosphorus Metabolic Process N-terminal Peptidyl-lysine Acetylation Protein Localization To Tight Junction Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Acetyl-CoA Biosynthetic Process Angiotensin-activated Signaling Pathway Lysine Catabolic Process Protein Localization To Cell Junction Positive Regulation By Host Of Viral Transcription Detoxification Of Mercury Ion Carbohydrate Metabolic Process N-terminal Protein Amino Acid Acetylation Response To Hypoxia Regulation Of Cellular Process Small Molecule Metabolic Process Apoptotic Signaling Pathway Sperm Capacitation Actin Crosslink Formation Branched-chain Amino Acid Catabolic Process Regulation Of Androgen Receptor Signaling Pathway Acetyl-CoA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Mercury Ion N-terminal Protein Amino Acid Modification
Tagcloud ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238
Tagcloud (Difference) ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238
Tagcloud (Intersection) ?