EWSR1 and SEC24A

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EWSR1	SEC24A
Gene Name		EWS RNA-binding protein 1	SEC24 family member A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding	Molecular_function Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process COPII Vesicle Coating Positive Regulation Of Protein Secretion Membrane Organization Positive Regulation Of Cholesterol Homeostasis
Pathways			Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation COPII (Coat Protein 2) Mediated Vesicle Transport ER to Golgi Transport Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	4 interactors: CBFA2T3 EWSR1 TFG TRIP13
Entrez ID		2130	10802
HPRD ID		00592	08456
Ensembl ID		ENSG00000182944	ENSG00000113615
Uniprot IDs		Q01844	B4E205 O95486
PDB IDs		2CPE	2NUP 2NUT 3EGD 3EGX
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death
Tagcloud ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	cargoes coated compensation considerably copii deficiency dispensable embryonic exhibiting fourth golgi haploinsufficient hepatocytes homozygous hypocholesterolemic lethality mammals nascent null paralog paralogs phenotypically tube vertebrate vesicles
Tagcloud (Difference) ?		arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1	cargoes coated compensation considerably copii deficiency dispensable embryonic exhibiting fourth golgi haploinsufficient hepatocytes homozygous hypocholesterolemic lethality mammals nascent null paralog paralogs phenotypically tube vertebrate vesicles
Tagcloud (Intersection) ?