EWSR1 and POLR3A

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		EWSR1	POLR3A
Description		EWS RNA binding protein 1	RNA polymerase III subunit A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cajal Body Membrane	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytoplasm Cytosol Membrane
	Molecular Function	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Magnesium Ion Binding DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding
	Biological Process	Regulation Of DNA-templated Transcription	Immune System Process DNA-templated Transcription Positive Regulation Of Gene Expression Positive Regulation Of Interferon-beta Production TRNA Transcription By RNA Polymerase III Innate Immune Response Defense Response To Virus
Pathways			Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases		Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue
GWAS		Breast cancer ( 23535729) Pancreatic cancer ( 25086665) Platelet count ( 27863252) Platelet distribution width ( 32888494)	Colorectal cancer or advanced adenoma ( 30510241) Executive function (trail making test B) ( 24629169)
Interacting Genes		164 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BRME1 BTK C11orf16 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CEBPA CETP CFAP298 CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 OGT PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B PTP4A2 RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	6 interacting genes: EWSR1 IKBKG NEDD4 PCBD1 PKP2 POLR3E
Entrez ID		2130	11128
HPRD ID		00592	17879
Ensembl ID		ENSG00000182944	ENSG00000148606
Uniprot IDs		A0A0D9SFL3 Q01844	O14802
PDB IDs		2CPE	7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Transcription Regulator Complex Chromatin Remodeling MRNA Metabolic Process Brahma Complex NpBAF Complex RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Chromatin Single-stranded DNA Binding Protein-containing Complex Negative Regulation Of DNA-templated Transcription Cardiac Conduction System Development Chromatin Binding Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Nucleosome Disassembly TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process	Nucleoplasm Ubiquitin Ligase Complex Channel Inhibitor Activity Regulation Of Sodium Ion Transport Formation Of Structure Involved In A Symbiotic Process 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Maintenance Of Protein Localization At Cell Tip Transmembrane Transporter Binding Innate Immune Response Phosphothreonine Residue Binding Linear Polyubiquitin Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Defense Response To Other Organism Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Macroautophagy Negative Regulation Of Potassium Ion Export Across Plasma Membrane Defense Response To Symbiont Maintenance Of Animal Organ Identity Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Nucleus Sodium Channel Inhibitor Activity Protein Domain Specific Binding Tetrahydrobiopterin Biosynthetic Process Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Intermediate Filament Bundle Assembly Desmosome Assembly IkappaB Kinase Complex Tetrahydrobiopterin Metabolic Process Potassium Channel Inhibitor Activity Alpha-catenin Binding Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Regulation Of Ventricular Cardiac Muscle Cell Action Potential Transferrin Receptor Binding Anoikis Endocardial Cushion Development Response To Other Organism Negative Regulation Of Sodium Ion Transport Pteridine-containing Compound Biosynthetic Process Desmosome Organization
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