EWSR1 and HMGN4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		EWSR1	HMGN4
Description		EWS RNA binding protein 1	high mobility group nucleosomal binding domain 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cajal Body Membrane	Chromatin Nucleus
	Molecular Function	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription	Chromatin Organization
Pathways
Drugs
Diseases		Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue
GWAS		Breast cancer ( 23535729) Pancreatic cancer ( 25086665) Platelet count ( 27863252) Platelet distribution width ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Small cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		164 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BRME1 BTK C11orf16 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CEBPA CETP CFAP298 CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 OGT PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B PTP4A2 RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383	8 interacting genes: CEBPA EWSR1 HPF1 PARP1 SMO TERF1 TERF2 TERF2IP
Entrez ID		2130	10473
HPRD ID		00592	17111
Ensembl ID		ENSG00000182944	ENSG00000182952
Uniprot IDs		A0A0D9SFL3 Q01844	O00479
PDB IDs		2CPE
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Transcription Regulator Complex Chromatin Remodeling MRNA Metabolic Process Brahma Complex NpBAF Complex RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Chromatin Single-stranded DNA Binding Protein-containing Complex Negative Regulation Of DNA-templated Transcription Cardiac Conduction System Development Chromatin Binding Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Nucleosome Disassembly TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process	Negative Regulation Of Telomere Maintenance Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Negative Regulation Of Chromosome Organization Telomere Maintenance Protein Localization To Chromosome Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Protein Localization To Organelle Telomerase Activity Protection From Non-homologous End Joining At Telomere Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Chromosome Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding DNA Metabolic Process DNA Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Nuclear Body Nucleobase-containing Compound Biosynthetic Process Telomere Maintenance In Response To DNA Damage Protein Poly-ADP-ribosylation Regulation Of DNA Recombination Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling Nucleic Acid Metabolic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process
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