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TRAF3 and TRAF3IP1
Number of citations of the paper that reports this interaction (PubMedID
10791955
)
0
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
TRAF3
TRAF3IP1
Description
TNF receptor associated factor 3
TRAF3 interacting protein 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytoplasm
Mitochondrion
Endosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Membrane
CD40 Receptor Complex
Serine/threonine Protein Kinase Complex
Fibrillar Center
Nucleoplasm
Cytoplasm
Centrosome
Cytoskeleton
Cilium
Axoneme
Nuclear Body
Intraciliary Transport Particle B
Ciliary Transition Zone
Ciliary Basal Body
Cell Projection
Ciliary Tip
Ciliary Base
Molecular Function
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Microtubule Binding
Biological Process
Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
Immune System Process
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Toll Signaling Pathway
MRNA Transcription
Regulation Of Proteolysis
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Regulation Of Interferon-beta Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Defense Response To Virus
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Antiviral Innate Immune Response
Morphogenesis Of A Polarized Epithelium
Kidney Development
Negative Regulation Of Protein Phosphorylation
Neural Tube Patterning
Cell Projection Organization
Embryonic Camera-type Eye Development
Negative Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Type I Interferon Production
Negative Regulation Of Interferon-beta Production
Embryonic Heart Tube Development
Intraciliary Anterograde Transport
Post-anal Tail Morphogenesis
Intraciliary Transport
Embryonic Digit Morphogenesis
Negative Regulation Of Smoothened Signaling Pathway
Animal Organ Development
System Development
Negative Regulation Of Defense Response To Virus
Defense Response To Virus
Cilium Assembly
Regulation Of Microtubule Cytoskeleton Organization
Pathways
TRAF3 deficiency - HSE
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Intraflagellar transport
Intraflagellar transport
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Age at first birth (
34211149
)
Age at first sexual intercourse (
34211149
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Asthma (
32296059
)
Asthma (childhood onset) (
30929738
)
Body mass index (
29273807
25673413
)
Body size at age 10 (
32376654
)
Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) (
19023125
)
Composite immunoglobulin trait (IgA x IgG/IgM) (
28628107
)
Eczema (
31361310
)
Gallstone disease (
30692554
)
Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment (
33608531
)
HDL cholesterol levels (
32203549
)
Immunoglobulin measurement (zinc sulfate turbidity test) (
29403010
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Major depressive disorder (MTAG) (
33479212
)
Monocyte count (
32888494
)
Multiple sclerosis (
24076602
31604244
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Red blood cell count (
32888494
)
Serum total protein levels (
29403010
)
Systemic lupus erythematosus (
33536424
28714469
)
Type 2 diabetes (
32499647
)
Chronotype (
30696823
)
FEV1 (
30804560
)
Intraocular pressure (
29617998
29785010
30054594
)
Iris characteristics (
21835309
)
Lung function (FEV1/FVC) (
28166213
30804560
)
Metabolite levels (
23823483
)
Morning person (
30696823
)
Refractive astigmatism (
30306274
)
Refractive error (
32231278
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
86 interacting genes:
ABCC1
ALPL
APOBEC3C
ASCC1
AZI2
BEX3
BIVM
C10orf62
CASP3
CCDC13
CCDC184
CD27
CD40
CDC37
CELF2
DAXX
EDA2R
EDAR
EWSR1
FAS
GMEB2
GRIN1
GRIN2D
HEMGN
HNRNPC
IFT25
IL15
IP6K3
IRF1
LNX1
LTBR
MAP2K1
MAP3K14
MAP3K7
MAVS
MFF
NEDD4L
NTAQ1
NUP62
OTUD5
PDLIM7
PDZD4
PIAS2
POM121
PSMB8
PTPN6
RAD23A
RIPK1
RIPPLY1
RNF216
RNF4
RRAS2
SAR1A
SHANK3
SRC
STK38
TANK
TBK1
TDP2
TICAM1
TNFRSF11A
TNFRSF12A
TNFRSF13C
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TRADD
TRAF2
TRAF3IP1
TRAF3IP2
TRAF3IP3
TRAF5
TRIM24
TRIM37
UBE2I
USP7
ZBP1
ZBTB49
ZMYND11
ZSCAN4
31 interacting genes:
ABI2
APP
CCDC93
CCNA2
CDC5L
DISC1
DMD
DST
DTNBP1
EXOC1
FRMD4A
GOLGA4
IL13RA1
IMMT
ITSN1
MACF1
OLFM1
PCNT
SFR1
SGF29
SMC2
SMC3
SMC4
SNAP91
SPTBN1
TAB2
TRAF3
TRAF6
TRAK1
UBXN10
WAC
Entrez ID
7187
26146
HPRD ID
03539
09571
Ensembl ID
ENSG00000131323
ENSG00000204104
Uniprot IDs
A6NHG8
Q13114
Q8TDR0
PDB IDs
1FLK
1FLL
1KZZ
1L0A
1RF3
1ZMS
2ECY
2GKW
8T5P
2EQO
8KCQ
Enriched GO Terms of Interacting Partners
?
Tumor Necrosis Factor-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor Receptor Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway
Apoptotic Process
Cell Death
Programmed Cell Death
Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Defense Response
Tumor Necrosis Factor Receptor Superfamily Complex
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Type I Interferon Production
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Defense Response
Signaling Receptor Activity
Positive Regulation Of Gene Expression
Death-inducing Signaling Complex
Defense Response To Virus
Regulation Of Cell Communication
Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Mononuclear Cell Proliferation
Regulation Of JNK Cascade
Cellular Response To Mechanical Stimulus
Regulation Of Gene Expression
Intracellular Signal Transduction
Response To Stress
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
CD40 Signaling Pathway
Regulation Of Leukocyte Proliferation
Regulation Of Immune System Process
Regulation Of MAPK Cascade
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cytokine Production
Immune Response
Response To External Biotic Stimulus
Positive Regulation Of Type I Interferon Production
Golgi To Plasma Membrane Transport
Post-Golgi Vesicle-mediated Transport
Positive Regulation Of Cellular Component Organization
Vesicle-mediated Transport To The Plasma Membrane
Regulation Of Postsynapse Organization
Organelle Organization
Regulation Of Neuron Projection Development
Positive Regulation Of Axonogenesis
Axo-dendritic Transport
Regulation Of Axon Extension
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Projection Organization
Golgi To Plasma Membrane Protein Transport
Cytoskeleton Organization
Positive Regulation Of Axon Extension
Meiotic Chromosome Condensation
Establishment Of Protein Localization
Condensin Complex
Positive Regulation Of Chromosome Condensation
Cilium Assembly
Positive Regulation Of Cell Differentiation
Regulation Of Axonogenesis
Golgi Vesicle Transport
Regulation Of Dendritic Spine Development
Dendritic Spine
Establishment Of Protein Localization To Plasma Membrane
Vesicle-mediated Transport
Cilium Organization
CD40 Receptor Complex
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Synapse Organization
Axon Cytoplasm
Axonal Transport
Cellular Localization
Organelle Assembly
Regulation Of Developmental Growth
Transport Along Microtubule
Clathrin-coated Pit
MyD88-independent Toll-like Receptor Signaling Pathway
Meiotic Chromosome Segregation
Regulation Of Chromosome Condensation
Endosome
Molecular Adaptor Activity
Cytoskeleton-dependent Intracellular Transport
Positive Regulation Of Developmental Process
Plasma Membrane Bounded Cell Projection Assembly
Signaling Adaptor Activity
Mitotic Chromosome Condensation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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