TRAF3 and PTPN6

Number of citations of the paper that reports this interaction (PubMedID 32779804)
48

Data Source:
BioGRID (pull down)

		TRAF3	PTPN6
Description		TNF receptor associated factor 3	protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane Endosome Membrane Membrane CD40 Receptor Complex Serine/threonine Protein Kinase Complex	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Specific Granule Lumen Alpha-beta T Cell Receptor Complex Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding Cell Adhesion Molecule Binding Phosphorylation-dependent Protein Binding
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Immune System Process Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Toll Signaling Pathway MRNA Transcription Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response	MAPK Cascade Mitotic Cell Cycle Pattern Recognition Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Neutrophil Activation Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Mast Cell Activation Involved In Immune Response Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Megakaryocyte Development T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding CD27 Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neutrophil Activation Epididymis Development Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		TRAF3 deficiency - HSE TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	GPVI-mediated activation cascade Regulation of KIT signaling Signaling by ALK PECAM1 interactions Co-inhibition by PD-1 Signal regulatory protein family interactions Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling CD22 mediated BCR regulation Neutrophil degranulation Interferon gamma signaling Regulation of IFNG signaling Interleukin-37 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA/IFNB signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Co-inhibition by BTLA
Drugs			Tiludronic acid
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Asthma (childhood onset) ( 30929738) Body mass index ( 29273807 25673413) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Eczema ( 31361310) Gallstone disease ( 30692554) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) HDL cholesterol levels ( 32203549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Major depressive disorder (MTAG) ( 33479212) Monocyte count ( 32888494) Multiple sclerosis ( 24076602 31604244) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Red blood cell count ( 32888494) Serum total protein levels ( 29403010) Systemic lupus erythematosus ( 33536424 28714469) Type 2 diabetes ( 32499647)	Mean corpuscular hemoglobin concentration ( 29403010) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		86 interacting genes: ABCC1 ALPL APOBEC3C ASCC1 AZI2 BEX3 BIVM C10orf62 CASP3 CCDC13 CCDC184 CD27 CD40 CDC37 CELF2 DAXX EDA2R EDAR EWSR1 FAS GMEB2 GRIN1 GRIN2D HEMGN HNRNPC IFT25 IL15 IP6K3 IRF1 LNX1 LTBR MAP2K1 MAP3K14 MAP3K7 MAVS MFF NEDD4L NTAQ1 NUP62 OTUD5 PDLIM7 PDZD4 PIAS2 POM121 PSMB8 PTPN6 RAD23A RIPK1 RIPPLY1 RNF216 RNF4 RRAS2 SAR1A SHANK3 SRC STK38 TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM24 TRIM37 UBE2I USP7 ZBP1 ZBTB49 ZMYND11 ZSCAN4	118 interacting genes: AATK ABL1 ACTN1 ACTN4 BCR BLNK BTLA CAV1 CBL CCDC88A CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CDK1 CEACAM1 CLEC4A CNKSR1 CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ERBB2 ERBB3 ERBB4 ESR1 FAS FCGR2B FCRL3 FGFR4 FHL3 FLT3 GAB2 GHR GRB2 H2BC3 HOXA10 IFNAR1 IGF1R IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRA1P KLRB1 KLRC1 LAIR1 LAT LCK LCP2 LIFR LILRB2 LILRB4 LMTK2 LYN MPIG6B MS4A2 MYH9 NOS1 OLIG1 PAG1 PDGFRB PECAM1 PIK3R1 PILRA PILRB PLCG2 PRKCA PRKCD PTK2B PTK7 PTPN11 PTPRC ROR1 ROR2 ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SNCA SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF3 TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID		7187	5777
HPRD ID		03539	01475
Ensembl ID		ENSG00000131323	ENSG00000111679
Uniprot IDs		A6NHG8 Q13114	P29350 Q53XS4
PDB IDs		1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW 8T5P	1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ 6SM5 8YHI
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Apoptotic Process Cell Death Programmed Cell Death Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Defense Response Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon Production Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Defense Response Signaling Receptor Activity Positive Regulation Of Gene Expression Death-inducing Signaling Complex Defense Response To Virus Regulation Of Cell Communication Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Mononuclear Cell Proliferation Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Regulation Of Gene Expression Intracellular Signal Transduction Response To Stress Positive Regulation Of Metabolic Process Regulation Of Metabolic Process CD40 Signaling Pathway Regulation Of Leukocyte Proliferation Regulation Of Immune System Process Regulation Of MAPK Cascade Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cytokine Production Immune Response Response To External Biotic Stimulus Positive Regulation Of Type I Interferon Production	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Immune Response Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Immune System Process Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Leukocyte Activation Cell Activation Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Membrane Lymphocyte Activation Receptor Complex Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Intracellular Signal Transduction Immune Response Positive Regulation Of Intracellular Signal Transduction Adaptive Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Phosphatase Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Protein Phosphorylation Regulation Of Leukocyte Proliferation External Side Of Plasma Membrane Fc Receptor Signaling Pathway Kinase Activity Immune Response-activating Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Population Proliferation B Cell Activation Mononuclear Cell Differentiation
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