TRAF3 and STK38

Number of citations of the paper that reports this interaction (PubMedID 28219902)
36

Data Source:
BioGRID (pull down)

		TRAF3	STK38
Description		TNF receptor associated factor 3	serine/threonine kinase 38
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane Endosome Membrane Membrane CD40 Receptor Complex Serine/threonine Protein Kinase Complex	Nucleus Chromosome Cytoplasm Cytosol Site Of Double-strand Break Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Cadherin Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin-like Protein Reader Activity Histone Reader Activity UFM1-modified Protein Reader Activity
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Immune System Process Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Toll Signaling Pathway MRNA Transcription Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response	DNA Damage Checkpoint Signaling Chromatin Organization Protein Phosphorylation DNA Damage Response Negative Regulation Of Metabolic Process Intracellular Signal Transduction Protein Modification Process Negative Regulation Of MAP Kinase Activity Postsynapse Organization
Pathways		TRAF3 deficiency - HSE TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Asthma (childhood onset) ( 30929738) Body mass index ( 29273807 25673413) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Eczema ( 31361310) Gallstone disease ( 30692554) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) HDL cholesterol levels ( 32203549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Major depressive disorder (MTAG) ( 33479212) Monocyte count ( 32888494) Multiple sclerosis ( 24076602 31604244) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Red blood cell count ( 32888494) Serum total protein levels ( 29403010) Systemic lupus erythematosus ( 33536424 28714469) Type 2 diabetes ( 32499647)	Mean platelet volume ( 32888494) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		86 interacting genes: ABCC1 ALPL APOBEC3C ASCC1 AZI2 BEX3 BIVM C10orf62 CASP3 CCDC13 CCDC184 CD27 CD40 CDC37 CELF2 DAXX EDA2R EDAR EWSR1 FAS GMEB2 GRIN1 GRIN2D HEMGN HNRNPC IFT25 IL15 IP6K3 IRF1 LNX1 LTBR MAP2K1 MAP3K14 MAP3K7 MAVS MFF NEDD4L NTAQ1 NUP62 OTUD5 PDLIM7 PDZD4 PIAS2 POM121 PSMB8 PTPN6 RAD23A RIPK1 RIPPLY1 RNF216 RNF4 RRAS2 SAR1A SHANK3 SRC STK38 TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM24 TRIM37 UBE2I USP7 ZBP1 ZBTB49 ZMYND11 ZSCAN4	16 interacting genes: BANP CALM1 CTDP1 H2AC20 H2BC21 H3C6 HERC5 HRAS MOB2 S100B SENP2 TRAF3 TRIM14 TRIM25 YWHAB YWHAZ
Entrez ID		7187	11329
HPRD ID		03539	09511
Ensembl ID		ENSG00000131323	ENSG00000112079
Uniprot IDs		A6NHG8 Q13114	Q15208
PDB IDs		1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW 8T5P	1PSB 6BXI
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Apoptotic Process Cell Death Programmed Cell Death Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Defense Response Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon Production Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Defense Response Signaling Receptor Activity Positive Regulation Of Gene Expression Death-inducing Signaling Complex Defense Response To Virus Regulation Of Cell Communication Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Mononuclear Cell Proliferation Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Regulation Of Gene Expression Intracellular Signal Transduction Response To Stress Positive Regulation Of Metabolic Process Regulation Of Metabolic Process CD40 Signaling Pathway Regulation Of Leukocyte Proliferation Regulation Of Immune System Process Regulation Of MAPK Cascade Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cytokine Production Immune Response Response To External Biotic Stimulus Positive Regulation Of Type I Interferon Production	Defense Response To Other Organism Innate Immune Response Phosphoserine Residue Binding Response To Other Organism Defense Response To Symbiont Nucleus Immune Response Structural Constituent Of Chromatin Response To External Biotic Stimulus Defense Response Nucleoplasm Cadherin Binding Nucleosome Ubiquitin Protein Ligase Activity Perinuclear Region Of Cytoplasm Protein Sequestering Activity Regulation Of Synaptic Plasticity Immune System Process Negative Regulation Of Protein Localization To Nucleus Long-term Synaptic Potentiation Cytoplasm Regulation Of Neuronal Synaptic Plasticity MRNA Transcription Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity GTPase Complex Regulation Of Defense Response To Virus Ubiquitin-protein Transferase Activity Synaptic Target Recognition TFIIF-class Transcription Factor Complex Binding PKR/eIFalpha Signaling Defense Response To Virus Calcium-dependent Protein Binding Cytosol Antiviral Innate Immune Response Protein Modification Process
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