TRAF3 and TNFRSF19

Number of citations of the paper that reports this interaction (PMID 10809768)
13

Data Source:
HPRD (in vivo)

		TRAF3	TNFRSF19
Gene Name		TNF receptor-associated factor 3	tumor necrosis factor receptor superfamily, member 19
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	Tumor Necrosis Factor-activated Receptor Activity
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Defense Response To Virus	Hair Follicle Development Apoptotic Process JNK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125)	Hypothyroidism ( 22493691) Nasopharyngeal carcinoma ( 20512145) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		55 interactors: ABCC1 ALPL APOBEC3C AZI2 BIRC3 CASP3 CD27 CD40 DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D IL15 IRF1 LTBR MAP2K1 MAP3K14 NGFRAP1 NUP62 OTUD5 PDLIM7 RIPK1 RRAS2 SAR1A SRC TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11	5 interactors: TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		7187	55504
HPRD ID		03539	05838
Ensembl ID		ENSG00000131323	ENSG00000127863
Uniprot IDs		A6NHG8 Q13114	Q9NS68
PDB IDs		1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?		Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Regulation Of Cytokine Production Signal Transduction Positive Regulation Of Protein Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Extrinsic Apoptotic Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Response To Stimulus Immune Response Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Regulation Of Apoptotic Process Response To Cytokine Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Lymphocyte Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Death	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Modification By Small Protein Conjugation Regulation Of Immunoglobulin Secretion Positive Regulation Of Innate Immune Response Positive Regulation Of T Cell Cytokine Production Regulation Of Innate Immune Response Regulation Of T Cell Cytokine Production Activation Of NF-kappaB-inducing Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-2 Production NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Protein Autoubiquitination Positive Regulation Of Cytokine Production Involved In Immune Response I-kappaB Kinase/NF-kappaB Signaling Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cytokine Production Regulation Of JUN Kinase Activity Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Positive Regulation Of Immune Response Positive Regulation Of T Cell Mediated Immunity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Cytokine Positive Regulation Of Binding
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction	adamts4 affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput turnover
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction	adamts4 affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput turnover
Tagcloud (Intersection) ?