KCTD6 and CDC23

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KCTD6	CDC23
Gene Name		potassium channel tetramerization domain containing 6	cell division cycle 23
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Intracellular Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Ankyrin Binding	Ubiquitin-protein Transferase Activity
	Biological Process	Protein Homooligomerization	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Regulation Of Exit From Mitosis Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: ACTN1 ACTN3 ANK1 C8orf33 CDC23 CTNND1 CUL3 EHHADH FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 PPIG PRPF31 SDCBP UBC ZCCHC10	44 interactors: ANAPC10 ANAPC13 APOL1 ATRIP BCAS3 BYSL CCDC24 CCDC36 CDC16 CDH1 CDT1 CEP44 COIL CRACR2A CTBP1 CYB5R2 DLX6-AS1 EIF5A2 FAM9B FBXO5 GORASP2 HEMK1 INCA1 INPP5J KCTD6 KDM1A LZTS2 MAPK3 OPTN PNMA5 RAC1 RAD54B RBM15B RBPMS RSL24D1 SIAH1 SLC52A2 SOX5 SPERT SSX2IP SUV39H1 TRIM27 TSC22D4 UBE2S
Entrez ID		200845	8697
HPRD ID		13769	07221
Ensembl ID		ENSG00000168301	ENSG00000094880
Uniprot IDs		Q8NC69	Q9UJX2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Adherens Junction Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Mitotic Metaphase Plate Congression Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Focal Adhesion Assembly Metaphase Plate Congression Modification-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Cell Junction Assembly Proteolysis Involved In Cellular Protein Catabolic Process Cell-cell Junction Organization Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Protein Ubiquitination Regulation Of Canonical Wnt Signaling Pathway Establishment Of Chromosome Localization Regulation Of Cell Cycle Phase Transition Adherens Junction Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Actin Filament-based Process Cell-substrate Junction Assembly Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Establishment Of Localization In Cell Positive Regulation Of Proteolysis Actin Filament Bundle Assembly Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Wnt Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Sister Chromatid Segregation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Chromosome Segregation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Protein K11-linked Ubiquitination Cell Cycle Regulation Of Organelle Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Protein Polyubiquitination Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Process Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Division Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transferase Activity Protein Ubiquitination Cell Cycle Checkpoint Protein Modification By Small Protein Conjugation Activation Of Anaphase-promoting Complex Activity Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			34c annexin arrest atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine
Tagcloud (Difference) ?			34c annexin arrest atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine
Tagcloud (Intersection) ?