KCTD6 and ANK1

Number of citations of the paper that reports this interaction (PubMedID 22573887)
74

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KCTD6	ANK1
Description		potassium channel tetramerization domain containing 6	ankyrin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol M Band	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band A Band Sarcolemma Neuron Projection Postsynaptic Membrane Cell Periphery Ankyrin-1 Complex
	Molecular Function	Protein Binding Ankyrin Binding Identical Protein Binding Cullin Family Protein Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Transmembrane Transporter Binding ATPase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Golgi Vesicle Transport Protein Localization To Plasma Membrane
Pathways		RUNX1 regulates estrogen receptor mediated transcription Neddylation Estrogen-dependent gene expression Antigen processing: Ubiquitination & Proteasome degradation	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport
Drugs
Diseases			Hereditary spherocytosis (SPH)
GWAS		Hepcidin/transferrin saturation ratio ( 27846281) Refractive error ( 32231278) Systemic lupus erythematosus ( 28714469) vWF levels ( 30586737)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758 27680694) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Glycated hemoglobin levels ( 20858683 34059833 31213470 24647736 28898252) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Insulin levels adjusted for BMI ( 24699409) LDL cholesterol levels ( 32203549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 28017375 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Pulmonary function decline ( 22424883) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration ( 30531941) Type 2 diabetes ( 22456796 32499647 22885922 24509480 26818947 28869590 29358691 30054458 30297969 30718926)
Interacting Genes		26 interacting genes: ACTN1 ACTN3 ANK1 BAG4 C8orf33 CDC23 CTNND1 ERBB2 FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 MOS NTAQ1 PICK1 PPIG PRPF31 PSMA1 REL SDCBP TBC1D2 TCEANC TEPSIN ZCCHC10	28 interacting genes: BLOC1S6 CD44 EMD EMP1 EPB42 FXYD3 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC NRM OBSCN RBFA RHAG RTP2 RYR1 SLC30A8 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB STRIT1 TIAM1 TMEM203 TTN
Entrez ID		200845	286
HPRD ID		13769	01693
Ensembl ID		ENSG00000168301	ENSG00000029534
Uniprot IDs		Q8NC69	B3KX39 P16157
PDB IDs			1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2 7TW3 7TW5 7TW6 7UZQ 7UZU 7V0K 7V0M 7V0S 7V0X 8CS9 8CSL 8CSV 8CTE
Enriched GO Terms of Interacting Partners?			Ankyrin Binding Ankyrin-1 Complex Spectrin Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Z Disc Chemical Homeostasis Bicarbonate Transport Plasma Membrane M Band Cortical Cytoskeleton Structural Constituent Of Cytoskeleton Intracellular Chemical Homeostasis Actin Filament Binding Actin Filament Capping Homeostatic Process Negative Regulation Of Actin Filament Depolymerization Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Cellular Homeostasis Bicarbonate Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Membrane Intracellularly Gated Calcium Channel Activity Monoatomic Anion Transmembrane Transporter Activity Cortical Actin Cytoskeleton Inorganic Ion Transmembrane Transport Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Sarcoplasmic Reticulum Cell Cortex Negative Regulation Of Protein-containing Complex Disassembly Actin Cytoskeleton Organization Calmodulin Binding Transmembrane Transport Regulation Of Protein Depolymerization Intracellular Monoatomic Cation Homeostasis Actin Filament-based Process Antiporter Activity Secretory Granule Membrane Chloride Transmembrane Transport Focal Adhesion Cell-matrix Adhesion Chloride Transport Cytoplasmic Side Of Plasma Membrane Multicellular Organismal-level Iron Ion Homeostasis I Band Cell-cell Contact Zone
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