KCTD6 and CTNND1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCTD6	CTNND1
Description		potassium channel tetramerization domain containing 6	catenin delta 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol M Band	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Membrane Catenin Complex Midbody Ciliary Basal Body Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Ankyrin Binding Identical Protein Binding Cullin Family Protein Binding	Signaling Receptor Binding Protein Binding Phosphatase Inhibitor Activity Phosphatase Binding Cadherin Binding Cell-cell Adhesion Mediator Activity Protein Sequestering Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization	Negative Regulation Of Transcription By RNA Polymerase II Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Negative Regulation Of D-glucose Transmembrane Transport Wnt Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Stabilization Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Intracellular Signal Transduction D-glucose Transmembrane Transport Negative Regulation Of Blood Vessel Branching
Pathways		RUNX1 regulates estrogen receptor mediated transcription Neddylation Estrogen-dependent gene expression Antigen processing: Ubiquitination & Proteasome degradation	Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions
Drugs
Diseases
GWAS		Hepcidin/transferrin saturation ratio ( 27846281) Refractive error ( 32231278) Systemic lupus erythematosus ( 28714469) vWF levels ( 30586737)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) Parkinson's disease ( 27182965) Pulse pressure ( 27841878 30578418) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878)
Interacting Genes		26 interacting genes: ACTN1 ACTN3 ANK1 BAG4 C8orf33 CDC23 CTNND1 ERBB2 FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 MOS NTAQ1 PICK1 PPIG PRPF31 PSMA1 REL SDCBP TBC1D2 TCEANC TEPSIN ZCCHC10	36 interacting genes: ACTA1 APP CDH1 CDH11 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR EIF4A3 EIF4G3 ERBIN FER GRIK2 GSK3B JUP KCTD6 MAPK1 MAPK3 MTNR1B MUC1 PLPP3 PSEN1 PTPN6 PTPRJ PTPRM RNF26 RPS6KA3 SMURF1 SNCA SRC SUMO2 WEE2-AS1 YWHAG ZBTB33
Entrez ID		200845	1500
HPRD ID		13769	03026
Ensembl ID		ENSG00000168301	ENSG00000198561
Uniprot IDs		Q8NC69	O60716
PDB IDs			3L6X 3L6Y
Enriched GO Terms of Interacting Partners?			Cadherin Binding Cell Adhesion Cell Junction Organization Regulation Of Multicellular Organismal Process Cell Junction Regulation Of Cell Communication Regulation Of Signaling Catenin Complex Beta-catenin Binding Regulation Of Signal Transduction Regulation Of Locomotion Cell Junction Assembly Negative Regulation Of Signaling Negative Regulation Of Cell Communication Adherens Junction Cell-cell Adhesion Cell-cell Adhesion Mediated By Cadherin Anchoring Junction Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Postsynapse Adherens Junction Organization Plasma Membrane Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Cell Migration Cell-cell Junction Assembly Regulation Of Cell Motility Cell-cell Junction Positive Regulation Of Metabolic Process Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Locomotion Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cell-cell Junction Organization Anatomical Structure Morphogenesis Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Positive Regulation Of Cell Migration Developmental Process Glutamatergic Synapse Regulation Of Metabolic Process Regulation Of Synaptic Plasticity Epidermal Growth Factor Receptor Signaling Pathway
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