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EEF1A1 and EXOSC4
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
EEF1A1
EXOSC4
Gene Name
eukaryotic translation elongation factor 1 alpha 1
exosome component 4
Image
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleolus
Cytoplasm
Cytosol
Eukaryotic Translation Elongation Factor 1 Complex
Plasma Membrane
Membrane
Extracellular Vesicular Exosome
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
Translation Elongation Factor Activity
GTPase Activity
Protein Binding
GTP Binding
Protein Kinase Binding
Poly(A) RNA Binding
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Translation
Translational Elongation
Gene Expression
Cellular Protein Metabolic Process
Cellular Response To Epidermal Growth Factor Stimulus
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Gene Expression
Positive Regulation Of Cell Growth
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
HSF1 activation
Translation
Cellular response to heat stress
Peptide chain elongation
Eukaryotic Translation Elongation
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
123 interactors:
ABTB2
ACTB
ALPL
ANKRD24
ANXA7
APLP1
ARIH2
AXIN1
BBS1
BBS2
BBS4
BRMS1
BTBD2
CASP2
CCDC130
CCL18
CDC25A
CDKN1A
CKS2
COX17
CRADD
CRCT1
CSRP2
DARS
DIABLO
DLEU1
DUSP7
DYNLL1
EIF3F
EXOSC4
FAS
GADD45A
GADD45G
GSK3B
HSPE1
HTRA2
IKBKG
IMMT
ITGB1BP1
ITSN1
KCNE3
KIF1B
KRAS
LAMA4
LAMTOR1
LAMTOR5
LSM3
MAD2L1BP
MAGED2
MAP3K14
MAPK14
MLLT3
MNAT1
MRM1
MRPL42
MTRNR2L1
MYOC
NEU1
NRAS
NREP
ORMDL3
PABPC4
PAEP
PAFAH1B3
PAPSS1
PCDHA4
PFN2
PHYHIP
PKN2
PLAUR
PLCG1
POLE2
POLR2C
PQBP1
PRKCD
PSG9
PSMD11
PTPN4
PTPRCAP
RAB27A
RAP2A
RBBP8
RFC5
RGS12
RNF10
RPA2
RPLP1
RRAS
RSRC1
SARS2
SDHAF2
SERPINB9
SFN
SHBG
SMAD2
SMAD4
SMN1
SNCA
SPP1
SSR1
STAT6
STMN2
SULT1E1
TAF9
TGIF1
TK1
TMPRSS3
TNFSF11
TP53BP2
TPT1
TRDMT1
TSPY1
TSPYL2
TTR
UBQLN4
WARS
XPO5
XRN2
YWHAG
ZBTB16
ZCCHC10
ZNF24
ZPR1
27 interactors:
AKR1A1
DIS3
DXO
EEF1A1
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FAHD1
GADD45GIP1
GTF2IRD1
HNRNPD
LRRC8D
MPP6
MPZL1
NEK1
SKIV2L
SKIV2L2
SMPD4
TSEN15
UPF1
UPF2
UPF3B
Entrez ID
1915
54512
HPRD ID
00559
16221
Ensembl ID
ENSG00000156508
ENSG00000178896
Uniprot IDs
P68104
Q6IPS9
Q9NPD3
PDB IDs
1SYW
2NN6
Enriched GO Terms of Interacting Partners
?
Apoptotic Process
Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cell Death
Death
Regulation Of Phosphorylation
Developmental Process
Regulation Of Phosphorus Metabolic Process
Response To Stimulus
Regulation Of Protein Kinase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Cell Differentiation
Anatomical Structure Development
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Organic Substance
Regulation Of Cell Death
Multicellular Organismal Development
Regulation Of Apoptotic Process
Cellular Response To Stimulus
Response To Stress
Cellular Response To Growth Factor Stimulus
Response To External Stimulus
Positive Regulation Of Protein Modification Process
Regulation Of Signaling
Cellular Response To Stress
Positive Regulation Of Programmed Cell Death
Response To Growth Factor
Positive Regulation Of Catalytic Activity
System Development
Positive Regulation Of Phosphorylation
Positive Regulation Of Cell Death
Regulation Of MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Nervous System Development
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transferase Activity
Apoptotic Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Kinase Activity
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Aromatic Compound Catabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
NcRNA Metabolic Process
Cellular Macromolecule Catabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
RRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Catabolic Process
Maturation Of 5.8S RRNA
RNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis
Gene Expression
Nucleic Acid Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Localization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Intracellular MRNA Localization
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
RNA Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cellular Metabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
RRNA 3'-end Processing
DNA Deamination
Histone MRNA Catabolic Process
Dosage Compensation By Inactivation Of X Chromosome
MRNA Export From Nucleus
Metabolic Process
Tagcloud
?
akap6
atf7
atxn1
bmpr2
categorize
deltan
grip2
gtf2f1
interactors
jbd
jbds
jnk1alpha1
jnk3
jnk3alpha1
jnks
kcne4
myo9b
nnat
pias1
ptgds
ptpn2
rabgap1
rusc2
shank1
sumo1
sypl1
tkt
topbp1
znf668
Tagcloud (Difference)
?
akap6
atf7
atxn1
bmpr2
categorize
deltan
grip2
gtf2f1
interactors
jbd
jbds
jnk1alpha1
jnk3
jnk3alpha1
jnks
kcne4
myo9b
nnat
pias1
ptgds
ptpn2
rabgap1
rusc2
shank1
sumo1
sypl1
tkt
topbp1
znf668
Tagcloud (Intersection)
?