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EXOSC4 and EXOSC3
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
EXOSC4
EXOSC3
Gene Name
exosome component 4
exosome component 3
Image
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Gene Expression
Positive Regulation Of Cell Growth
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Gene Expression
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Isotype Switching
Positive Regulation Of Isotype Switching
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
27 interactors:
AKR1A1
DIS3
DXO
EEF1A1
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FAHD1
GADD45GIP1
GTF2IRD1
HNRNPD
LRRC8D
MPP6
MPZL1
NEK1
SKIV2L
SKIV2L2
SMPD4
TSEN15
UPF1
UPF2
UPF3B
8 interactors:
APP
ATP5D
CDK5RAP1
EXOSC4
EXOSC5
EXOSC8
EXOSC9
KHSRP
Entrez ID
54512
51010
HPRD ID
16221
16220
Ensembl ID
ENSG00000178896
ENSG00000107371
Uniprot IDs
Q9NPD3
Q9NQT5
Q9NYS3
PDB IDs
2NN6
2NN6
Enriched GO Terms of Interacting Partners
?
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Aromatic Compound Catabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
NcRNA Metabolic Process
Cellular Macromolecule Catabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
RRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Catabolic Process
Maturation Of 5.8S RRNA
RNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis
Gene Expression
Nucleic Acid Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Localization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Intracellular MRNA Localization
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
RNA Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cellular Metabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
RRNA 3'-end Processing
DNA Deamination
Histone MRNA Catabolic Process
Dosage Compensation By Inactivation Of X Chromosome
MRNA Export From Nucleus
Metabolic Process
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
MRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Catabolic Process
MRNA Metabolic Process
RRNA Processing
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Aromatic Compound Catabolic Process
NcRNA Metabolic Process
Ribosome Biogenesis
Nuclear MRNA Surveillance
Nucleobase-containing Compound Metabolic Process
Ribonucleoprotein Complex Biogenesis
DNA Deamination
RNA Surveillance
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Catabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Phosphodiester Bond Hydrolysis
RNA Metabolic Process
Nitrogen Compound Metabolic Process
Catabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Gene Expression
DNA Modification
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Cell Growth
Regulation Of Growth
Collateral Sprouting In Absence Of Injury
Cellular Metabolic Process
Defense Response To Virus
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Collateral Sprouting
Axon Midline Choice Point Recognition
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Axon Choice Point Recognition
Positive Regulation Of Growth
Neuron Remodeling
Regulation Of MiRNA Metabolic Process
Histone MRNA Catabolic Process
Response To Virus
Immune System Process
RRNA Catabolic Process
Regulation Of Cell Growth
Mitochondrial ATP Synthesis Coupled Proton Transport
Maturation Of 5.8S RRNA
Tagcloud
?
aligned
amenable
avenues
baz2a
bioinformatic
candidates
cdk13
chem
dapk1
digest
dilution
dst
hdms
hierarchical
inhbe
kat2b
kif20b
linkages
noninvasive
pancreatic
proteomics
resectable
silva
smc1b
spag5
synapt
tryptic
unsupervised
urgent
Tagcloud (Difference)
?
aligned
amenable
avenues
baz2a
bioinformatic
candidates
cdk13
chem
dapk1
digest
dilution
dst
hdms
hierarchical
inhbe
kat2b
kif20b
linkages
noninvasive
pancreatic
proteomics
resectable
silva
smc1b
spag5
synapt
tryptic
unsupervised
urgent
Tagcloud (Intersection)
?