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EEF1A1 and POLR2C
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
EEF1A1
POLR2C
Description
eukaryotic translation elongation factor 1 alpha 1
RNA polymerase II subunit C
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleolus
Cytoplasm
Cytosol
Ribosome
Eukaryotic Translation Elongation Factor 1 Complex
Plasma Membrane
Membrane
Cytosolic Ribosome
Cortical Actin Cytoskeleton
Ruffle Membrane
Secretory Granule Lumen
Extracellular Exosome
Cytoplasmic Side Of Lysosomal Membrane
Ficolin-1-rich Granule Lumen
DNA-directed RNA Polymerase Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Cytosol
Molecular Function
TRNA Binding
Nucleotide Binding
RNA Binding
Translation Elongation Factor Activity
GTPase Activity
Protein Binding
GTP Binding
Hydrolase Activity
Kinase Activator Activity
Kinase Binding
Protein Kinase Binding
Molecular Adaptor Activity
DNA Binding
DNA-directed RNA Polymerase Activity
Protein Binding
Protein Dimerization Activity
Biological Process
Translation
Translational Elongation
Host-mediated Activation Of Viral Genome Replication
Cellular Response To Epidermal Growth Factor Stimulus
Regulation Of Chaperone-mediated Autophagy
DNA-templated Transcription
Transcription By RNA Polymerase II
Pathways
Eukaryotic Translation Elongation
Eukaryotic Translation Elongation
Peptide chain elongation
HSF1 activation
Neutrophil degranulation
Protein methylation
Chaperone Mediated Autophagy
SARS-CoV-1 modulates host translation machinery
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Drugs
Zinc
Guanosine-5'-Diphosphate
Copper
Artenimol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Interacting Genes
144 interacting genes:
ABTB2
ACTB
ALPL
ANKRD24
ANXA7
APLP1
AQP2
ARIH2
AXIN1
BBS1
BBS2
BBS4
BRMS1
BTBD2
CASP2
CCL18
CDC25A
CDKN1A
CEBPA
CKS2
CLIC6
COX17
CRADD
CRCT1
CREBBP
CSRP2
CTIF
DARS1
DCTN1
DIABLO
DLEU1
DNMT1
DNMT3A
DUSP7
DYNLL1
DYSF
EIF3F
EP300
EXOSC4
FAS
GADD45A
GADD45G
HOXA1
HSPB2
HSPE1
HTRA2
IKBKG
IMMT
ITGB1BP1
ITSN1
KCNE3
KIF1B
LAMA4
LAMTOR1
LAMTOR5
LSM3
MAD2L1BP
MAGED2
MAP3K14
MAPK14
MLLT3
MNAT1
MRM1
MRPL42
MTRNR2L1
MYOC
NEU1
NRAS
NREP
OGT
ORMDL3
PABPC4
PAEP
PAFAH1B3
PAPSS1
PCDHA4
PFN2
PHYHIP
PKN2
PLAUR
PLCG1
POLE2
POLR2C
PQBP1
PRKCD
PSG9
PSMD11
PTPN4
PTPRCAP
PTPRF
RAB27A
RAP2A
RFC5
RGS12
RND1
RNF10
RPA2
RPLP1
RRAS
RSRC1
SARS2
SDHAF2
SERPINB5
SERPINB9
SF3B4
SFN
SHBG
SMAD2
SMAD4
SMN1
SPATS2L
SPP1
SSR1
STAT6
STMN2
SULT1E1
SUMO2
TAF9
TGIF1
TK1
TMPRSS3
TNFSF11
TP53BP2
TPT1
TRDMT1
TSC2
TSPY1
TSPYL2
TTLL12
TTR
TXNIP
UBQLN4
USP40
VHL
WARS1
WEE2-AS1
XPO5
XRN2
YJU2B
YWHAG
ZBTB16
ZCCHC10
ZNF24
ZPR1
32 interacting genes:
ATF4
ATF7IP
C11orf58
CCHCR1
EEF1A1
ERG28
ITCH
LRIF1
MYOG
NECAB2
NEDD4
NFKBIA
NUDT21
OTUD5
POLR2A
POLR2B
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2J
POLR2J2
POLR2K
POLR2L
RPAP1
RSPH1
SMARCC2
STC2
TAF15
UBC
UBE2W
Entrez ID
1915
5432
HPRD ID
00559
15945
Ensembl ID
ENSG00000156508
ENSG00000102978
Uniprot IDs
P68104
Q6IPS9
P19387
Q6FGR6
PDB IDs
3C5J
6ZMO
8G60
8G6J
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
6XRE
7LBM
9EHZ
9EI1
9EI3
9EI4
Enriched GO Terms of Interacting Partners
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Cytoplasm
Apoptotic Process
Cell Death
Programmed Cell Death
Regulation Of Programmed Cell Death
Cytosol
Negative Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Negative Regulation Of Kinase Activity
Negative Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Phosphorylation
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Apoptotic Signaling Pathway
BBSome
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
TORC1 Signaling
Protein-containing Complex
Nucleus
Macromolecule Biosynthetic Process
Melanosome Transport
Tau Protein Binding
Regulation Of Developmental Process
RNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Establishment Of Melanosome Localization
Pigment Granule Transport
Negative Regulation Of Protein Phosphorylation
Cellular Response To Stress
Melanosome Localization
Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Macromolecule Metabolic Process
Positive Regulation Of Apoptotic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pigment Granule Localization
Mitochondrial Intermembrane Space
Nucleoplasm
Protein Binding
Negative Regulation Of Catalytic Activity
Histone H3K27 Acetyltransferase Activity
Negative Regulation Of Phosphate Metabolic Process
TOR Signaling
Positive Regulation Of TOR Signaling
Regulation Of Phosphorus Metabolic Process
RNA Polymerase II, Core Complex
DNA-directed RNA Polymerase Complex
DNA-directed RNA Polymerase Activity
Transcription By RNA Polymerase II
DNA-templated Transcription
RNA Polymerase I Complex
RNA Polymerase III Complex
Nucleobase-containing Compound Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleus
RNA Metabolic Process
Nucleoplasm
Nucleic Acid Metabolic Process
Transcription By RNA Polymerase III
TRNA Transcription By RNA Polymerase III
TRNA Transcription
Nucleobase-containing Compound Metabolic Process
RNA-directed RNA Polymerase Activity
RNA-templated Transcription
Macromolecule Metabolic Process
DNA Binding
Regulation Of Transcription By RNA Polymerase I
5'-3' RNA Polymerase Activity
Protein Monoubiquitination
Nucleolus
Transcription By RNA Polymerase I
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Nucleotidyltransferase Activity
Translation Initiation Factor Binding
Negative Regulation Of Gene Expression
Negative Regulation Of Potassium Ion Transport
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