EEF1A1 and WARS1

Number of citations of the paper that reports this interaction (PubMedID 11829477)
0

Data Source:
HPRD (two hybrid)

		EEF1A1	WARS1
Description		eukaryotic translation elongation factor 1 alpha 1	tryptophanyl-tRNA synthetase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Ribosome Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Cytosolic Ribosome Cortical Actin Cytoskeleton Ruffle Membrane Secretory Granule Lumen Extracellular Exosome Cytoplasmic Side Of Lysosomal Membrane Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Kinase Activator Activity Kinase Binding Protein Kinase Binding Molecular Adaptor Activity	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Tryptophan-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Kinase Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Translation Translational Elongation Host-mediated Activation Of Viral Genome Replication Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Chaperone-mediated Autophagy	Angiogenesis Translation TRNA Aminoacylation For Protein Translation Tryptophanyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Protein-containing Complex Assembly Regulation Of Angiogenesis
Pathways		Eukaryotic Translation Elongation Eukaryotic Translation Elongation Peptide chain elongation HSF1 activation Neutrophil degranulation Protein methylation Chaperone Mediated Autophagy SARS-CoV-1 modulates host translation machinery	Cytosolic tRNA aminoacylation
Drugs		Zinc Guanosine-5'-Diphosphate Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Tryptophan Tryptophanyl-5'amp Tryptophanamide
Diseases
GWAS
Interacting Genes		144 interacting genes: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 AQP2 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCL18 CDC25A CDKN1A CEBPA CKS2 CLIC6 COX17 CRADD CRCT1 CREBBP CSRP2 CTIF DARS1 DCTN1 DIABLO DLEU1 DNMT1 DNMT3A DUSP7 DYNLL1 DYSF EIF3F EP300 EXOSC4 FAS GADD45A GADD45G HOXA1 HSPB2 HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP OGT ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP PTPRF RAB27A RAP2A RFC5 RGS12 RND1 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB5 SERPINB9 SF3B4 SFN SHBG SMAD2 SMAD4 SMN1 SPATS2L SPP1 SSR1 STAT6 STMN2 SULT1E1 SUMO2 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSC2 TSPY1 TSPYL2 TTLL12 TTR TXNIP UBQLN4 USP40 VHL WARS1 WEE2-AS1 XPO5 XRN2 YJU2B YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1	15 interacting genes: APP CDK2AP2 CEBPA DCAF13 DNMT3B DSCAM EEF1A1 FILNC1 LCOR LIG4 LINC01554 MDH2 OGT TERF1 UBC
Entrez ID		1915	7453
HPRD ID		00559	01845
Ensembl ID		ENSG00000156508	ENSG00000140105
Uniprot IDs		P68104 Q6IPS9	A0A024R6K8 P23381
PDB IDs		3C5J 6ZMO 8G60 8G6J	1O5T 1R6T 1R6U 1ULH 2AKE 2AZX 2DR2 2QUH 2QUI 2QUJ 2QUK 5UJI 5UJJ
Enriched GO Terms of Interacting Partners?		Cytoplasm Apoptotic Process Cell Death Programmed Cell Death Regulation Of Programmed Cell Death Cytosol Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Negative Regulation Of Metabolic Process Regulation Of Apoptotic Process Nucleic Acid Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway BBSome Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Protein-containing Complex Nucleus Macromolecule Biosynthetic Process Melanosome Transport Tau Protein Binding Regulation Of Developmental Process RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Pigment Granule Transport Negative Regulation Of Protein Phosphorylation Cellular Response To Stress Melanosome Localization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Macromolecule Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pigment Granule Localization Mitochondrial Intermembrane Space Nucleoplasm Protein Binding Negative Regulation Of Catalytic Activity Histone H3K27 Acetyltransferase Activity Negative Regulation Of Phosphate Metabolic Process TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Phosphorus Metabolic Process	Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Neuron Recognition Nucleus Cellular Response To Metal Ion Response To Lithium Ion Cellular Response To Lithium Ion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency L-malate Dehydrogenase (NADP+) Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Estrogen Receptor Binding Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chromatin DNA Binding CHOP-C/EBP Complex Stem Cell Proliferation Response To Vitamin B2 C/EBP Complex DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Post-embryonic Retina Morphogenesis In Camera-type Eye
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