EXOSC4 and MPZL1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		EXOSC4	MPZL1
Description		exosome component 4	myelin protein zero like 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Plasma Membrane Focal Adhesion Cell Surface Membrane
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	Structural Molecule Activity Protein Binding
	Biological Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163)	Alzheimer's disease (late onset) ( 22881374) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		34 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PRRC2B PTEN SDCBP SKIC2 SMPD4 TSEN15 UPF1 UPF2 UPF3B WTAP	10 interacting genes: DOK7 EXOSC4 FBXO7 FHL3 MFF PTPN11 SRC STAT3 TRIM55 TRIM63
Entrez ID		54512	9019
HPRD ID		16221	05086
Ensembl ID		ENSG00000178896	ENSG00000197965
Uniprot IDs		Q9NPD3	A8K5D4 O95297
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	6IGO 6IGT 6IGW
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Catabolic Process Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nuclear RNA Surveillance Nuclear MRNA Surveillance RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing MRNA Metabolic Process RRNA 3'-end Processing TRNA Decay SnRNA Metabolic Process RNA Metabolic Process Macromolecule Catabolic Process SnRNA 3'-end Processing RRNA Processing 3'-5'-RNA Exonuclease Activity RRNA Metabolic Process SnRNA Processing RNA Binding Nucleic Acid Metabolic Process CUT Catabolic Process RRNA Catabolic Process RNA 3'-end Processing Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression RNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Macromolecule Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolus Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Sno(s)RNA Metabolic Process TRNA Metabolic Process Exoribonuclease Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process	Regulation Of Glycolytic Process Negative Regulation Of Neutrophil Activation Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Interleukin-6-mediated Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Glycolytic Process Protein Kinase Binding Negative Regulation Of ATP Metabolic Process Neutrophil Activation Protein Targeting To Mitochondrion Astrocyte Differentiation Negative Regulation Of Leukocyte Activation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Activation Immune System Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ATP Metabolic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Notch Signaling Pathway T Cell Costimulation Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Vasodilation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Canonical NF-kappaB Signal Transduction Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Epidermal Growth Factor Receptor Signaling Pathway Myeloid Cell Development Protein-containing Complex Positive Regulation Of Phosphate Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle ERBB Signaling Pathway Post-translational Protein Modification Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Cellular Component Organization Intestinal Epithelial Cell Migration Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
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