EXOSC4 and UPF3B

Number of citations of the paper that reports this interaction (PMID 14527413)
102

Data Source:
HPRD (in vitro, in vivo)

		EXOSC4	UPF3B
Gene Name		exosome component 4	UPF3 regulator of nonsense transcripts homolog B (yeast)
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Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding AU-rich Element Binding	Nucleotide Binding MRNA Binding Nucleocytoplasmic Transporter Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Positive Regulation Of Translation
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LRRC8D MPP6 MPZL1 NEK1 SKIV2L SKIV2L2 SMPD4 TSEN15 UPF1 UPF2 UPF3B	10 interactors: EIF6 EXOSC4 HBB MCRS1 RBBP6 RBM8A TTC19 UPF1 UPF2 XRN1
Entrez ID		54512	65109
HPRD ID		16221	02247
Ensembl ID		ENSG00000178896	ENSG00000125351
Uniprot IDs		Q9NPD3	Q9BZI7
PDB IDs		2NN6	1UW4 2XB2
Enriched GO Terms of Interacting Partners?		RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Maturation Of 5.8S RRNA RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing DNA Deamination Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome MRNA Export From Nucleus Metabolic Process	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Histone MRNA Catabolic Process RNA Catabolic Process Histone MRNA Metabolic Process Nuclear Export Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Catabolic Process MRNA Export From Nucleus Nuclear MRNA Surveillance Nucleocytoplasmic Transport Nuclear Transport RNA Export From Nucleus RNA Surveillance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Transport RNA Transport RNA Localization Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Gene Expression Cytoplasmic Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Nitric Oxide Transport RRNA Metabolic Process Mature Ribosome Assembly Intracellular Transport Ribosome Biogenesis Cellular Metabolic Process DNA Deamination Ribosomal Subunit Export From Nucleus Mitochondrial Respiratory Chain Complex III Assembly Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Dosage Compensation Renal Absorption Regulation Of Translation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Heterocycle Metabolic Process Histone H4-K16 Acetylation Cellular Aromatic Compound Metabolic Process Establishment Of Localization In Cell Nucleic Acid Phosphodiester Bond Hydrolysis Maturation Of 5.8S RRNA
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