EXOSC4 and AKR1A1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		EXOSC4	AKR1A1
Gene Name		exosome component 4	aldo-keto reductase family 1, member A1 (aldehyde reductase)
Image
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Extracellular Space Cytosol Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding AU-rich Element Binding	Alditol:NADP+ 1-oxidoreductase Activity Electron Carrier Activity L-glucuronate Reductase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Glucose Metabolic Process Cellular Aldehyde Metabolic Process L-ascorbic Acid Biosynthetic Process D-glucuronate Catabolic Process Aldehyde Catabolic Process Oxidation-reduction Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LRRC8D MPP6 MPZL1 NEK1 SKIV2L SKIV2L2 SMPD4 TSEN15 UPF1 UPF2 UPF3B	3 interactors: EXOSC4 TERF1 TERF2IP
Entrez ID		54512	10327
HPRD ID		16221	00069
Ensembl ID		ENSG00000178896	ENSG00000117448
Uniprot IDs		Q9NPD3	P14550
PDB IDs		2NN6	2ALR
Enriched GO Terms of Interacting Partners?		RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Maturation Of 5.8S RRNA RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing DNA Deamination Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome MRNA Export From Nucleus Metabolic Process	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Negative Regulation Of DNA Recombination At Telomere Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening DNA Replication Telomere Maintenance Via Telomere Shortening Regulation Of Cellular Component Organization Protection From Non-homologous End Joining At Telomere Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Nuclear MRNA Surveillance RNA Surveillance DNA Deamination Histone MRNA Catabolic Process Replicative Cell Aging Negative Regulation Of Telomerase Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomerase Activity Maturation Of 5.8S RRNA Histone MRNA Metabolic Process Negative Regulation Of DNA Recombination Negative Regulation Of DNA Biosynthetic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Double-strand Break Repair Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Microtubule Polymerization Protein Localization To Chromosome RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Mitotic Spindle Assembly Checkpoint Regulation Of Organelle Organization Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Chromosome Organization Regulation Of DNA Biosynthetic Process
Tagcloud ?			acceptors akr1c4 akrs aldo amplify catalyze catechols causation deoxyguanosine dihydrodiols diol dione epoxide exacerbating futile keto michael mutagen mutagenicity oxidoreductases pah promiscuous pyrene quinone quinones reductases reminiscent transversions
Tagcloud (Difference) ?			acceptors akr1c4 akrs aldo amplify catalyze catechols causation deoxyguanosine dihydrodiols diol dione epoxide exacerbating futile keto michael mutagen mutagenicity oxidoreductases pah promiscuous pyrene quinone quinones reductases reminiscent transversions
Tagcloud (Intersection) ?