Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
EXOSC4 and NEK1
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
EXOSC4
NEK1
Gene Name
exosome component 4
NIMA-related kinase 1
Image
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Pericentriolar Material
Nucleus
Cytoplasm
Centrosome
Molecular Function
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Gene Expression
Positive Regulation Of Cell Growth
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
MAPK Cascade
Activation Of MAPK Activity
Cellular Response To DNA Damage Stimulus
Mitotic Nuclear Division
Response To Ionizing Radiation
Peptidyl-tyrosine Phosphorylation
Cilium Assembly
Cell Division
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
27 interactors:
AKR1A1
DIS3
DXO
EEF1A1
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FAHD1
GADD45GIP1
GTF2IRD1
HNRNPD
LRRC8D
MPP6
MPZL1
NEK1
SKIV2L
SKIV2L2
SMPD4
TSEN15
UPF1
UPF2
UPF3B
13 interactors:
ATRX
CSN2
CTNNAL1
EXOSC4
FEZ1
FEZ2
KIF3A
MRE11A
PPP2R5A
TP53BP1
TSC2
YWHAH
ZNF350
Entrez ID
54512
4750
HPRD ID
16221
06847
Ensembl ID
ENSG00000178896
ENSG00000137601
Uniprot IDs
Q9NPD3
Q5JXL9
Q96PY6
PDB IDs
2NN6
4APC
4B9D
Enriched GO Terms of Interacting Partners
?
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Aromatic Compound Catabolic Process
Ribosome Biogenesis
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
NcRNA Metabolic Process
Cellular Macromolecule Catabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
RRNA Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Catabolic Process
Maturation Of 5.8S RRNA
RNA Metabolic Process
RNA Phosphodiester Bond Hydrolysis
Gene Expression
Nucleic Acid Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Localization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Intracellular MRNA Localization
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
RNA Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cellular Metabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
SnoRNA Metabolic Process
RRNA 3'-end Processing
DNA Deamination
Histone MRNA Catabolic Process
Dosage Compensation By Inactivation Of X Chromosome
MRNA Export From Nucleus
Metabolic Process
Response To Stimulus
Regulation Of Cellular Component Organization
Cellular Response To Stimulus
Negative Regulation Of Cellular Metabolic Process
Nervous System Development
Regulation Of Cellular Process
DNA Recombination
Glucocorticoid Catabolic Process
Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter
Regulation Of Dendrite Morphogenesis
DNA Duplex Unwinding
DNA Geometric Change
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Generation Of Neurons
DNA Modification
Neurogenesis
Positive Regulation Of Cellular Metabolic Process
Regulation Of Dendrite Development
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Lipid Kinase Activity
Cellular Response To Hydroxyurea
DNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Epidermal Stem Cell Homeostasis
Regulation Of DNA Replication
Signal Transduction
Neuron Differentiation
Negative Regulation Of DNA Endoreduplication
Positive Regulation Of Nuclear Cell Cycle DNA Replication
Protein Transport Into Plasma Membrane Raft
Cell Projection Organization
Double-strand Break Repair
System Development
Regulation Of Mitotic Recombination
Plus-end-directed Vesicle Transport Along Microtubule
Protein Localization To Plasma Membrane Raft
Regulation Of Transcription, DNA-templated
Nuclear MRNA Surveillance
DNA Repair
Chemotaxis
Signaling
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Metabolic Process
Cell Communication
Positive Regulation Of Transcription, DNA-templated
Regulation Of Endocytosis
Regulation Of RNA Metabolic Process
Cullin Deneddylation
Tagcloud
?
axin
cdk1
crb3
dock7
dsh
ezrin
fip200
gadd34
gsk3
hamartin
herc1
hscp
immunoprecipitate
melted
merlin
moesin
nade
p27kip1
p75ntr
pam
patj
pc1
pp2ac
rabaptin
radixin
rheb
rsk1
tbc7
tuberin
Tagcloud (Difference)
?
axin
cdk1
crb3
dock7
dsh
ezrin
fip200
gadd34
gsk3
hamartin
herc1
hscp
immunoprecipitate
melted
merlin
moesin
nade
p27kip1
p75ntr
pam
patj
pc1
pp2ac
rabaptin
radixin
rheb
rsk1
tbc7
tuberin
Tagcloud (Intersection)
?