EEF1A1 and TTR

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EEF1A1	TTR
Gene Name		eukaryotic translation elongation factor 1 alpha 1	transthyretin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Poly(A) RNA Binding	Hormone Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity Thyroid Hormone Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Elongation Gene Expression Cellular Protein Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus	Retinoid Metabolic Process Transport Phototransduction, Visible Light Extracellular Matrix Organization Retinol Metabolic Process Thyroid Hormone Transport
Pathways		HSF1 activation Translation Cellular response to heat stress Peptide chain elongation Eukaryotic Translation Elongation	Amyloids Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Non-integrin membrane-ECM interactions Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Retinol levels ( 21878437)
Protein-Protein Interactions		123 interactors: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCDC130 CCL18 CDC25A CDKN1A CKS2 COX17 CRADD CRCT1 CSRP2 DARS DIABLO DLEU1 DUSP7 DYNLL1 EIF3F EXOSC4 FAS GADD45A GADD45G GSK3B HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B KRAS LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP RAB27A RAP2A RBBP8 RFC5 RGS12 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB9 SFN SHBG SMAD2 SMAD4 SMN1 SNCA SPP1 SSR1 STAT6 STMN2 SULT1E1 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSPY1 TSPYL2 TTR UBQLN4 WARS XPO5 XRN2 YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1	46 interactors: A2M ACTB AGER APOA1 ASNA1 ATF4 BAG6 C14orf1 CDR2 CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 FEZ1 GET4 HNRNPH3 HSPG2 IKBKAP INPP5K KIAA1377 LRP2 MARK3 MT3 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1
Entrez ID		1915	7276
HPRD ID		00559	01447
Ensembl ID		ENSG00000156508	ENSG00000118271
Uniprot IDs		P68104 Q6IPS9	E9KL36 P02766
PDB IDs		1SYW	1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 5TTR
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Death Death Regulation Of Phosphorylation Developmental Process Regulation Of Phosphorus Metabolic Process Response To Stimulus Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Cell Differentiation Anatomical Structure Development Regulation Of Catalytic Activity Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Cell Death Multicellular Organismal Development Regulation Of Apoptotic Process Cellular Response To Stimulus Response To Stress Cellular Response To Growth Factor Stimulus Response To External Stimulus Positive Regulation Of Protein Modification Process Regulation Of Signaling Cellular Response To Stress Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Catalytic Activity System Development Positive Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Nervous System Development Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Kinase Activity	Protein Insertion Into ER Membrane Anatomical Structure Development Developmental Process Protein Stabilization Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Protein Stability Nervous System Development Central Nervous System Development Regulation Of Gene Expression Protein Insertion Into Membrane System Development Cellular Localization Phototransduction, Visible Light Retinoid Metabolic Process Detection Of Abiotic Stimulus Diterpenoid Metabolic Process Detection Of Visible Light Cellular Response To Stimulus Platelet Activation Phototransduction Response To Light Stimulus Chromatin Organization Regulation Of Glucose Transport Alcohol Metabolic Process Detection Of Light Stimulus Organelle Organization Establishment Of Protein Localization To Membrane Metabolic Process Lipid Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Cellular Metabolic Process Isoprenoid Metabolic Process Response To Organic Substance Endoplasmic Reticulum Organization Chromatin Modification Regulation Of Cellular Protein Metabolic Process Membrane Organization Response To Radiation Negative Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Response To Wounding Signaling Regulation Of Glucose Import Cellular Protein Modification Process
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Intersection) ?