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EEF1A1 and POLE2
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
EEF1A1
POLE2
Description
eukaryotic translation elongation factor 1 alpha 1
DNA polymerase epsilon 2, accessory subunit
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleolus
Cytoplasm
Cytosol
Ribosome
Eukaryotic Translation Elongation Factor 1 Complex
Plasma Membrane
Membrane
Cytosolic Ribosome
Cortical Actin Cytoskeleton
Ruffle Membrane
Secretory Granule Lumen
Extracellular Exosome
Cytoplasmic Side Of Lysosomal Membrane
Ficolin-1-rich Granule Lumen
Nucleus
Nucleoplasm
Chromosome
Epsilon DNA Polymerase Complex
Nuclear Body
Nuclear Lumen
Molecular Function
TRNA Binding
Nucleotide Binding
RNA Binding
Translation Elongation Factor Activity
GTPase Activity
Protein Binding
GTP Binding
Hydrolase Activity
Kinase Activator Activity
Kinase Binding
Protein Kinase Binding
Molecular Adaptor Activity
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Biological Process
Translation
Translational Elongation
Host-mediated Activation Of Viral Genome Replication
Cellular Response To Epidermal Growth Factor Stimulus
Regulation Of Chaperone-mediated Autophagy
DNA Metabolic Process
DNA Replication
DNA-templated DNA Replication
DNA Repair
Error-prone Translesion Synthesis
Pathways
Eukaryotic Translation Elongation
Eukaryotic Translation Elongation
Peptide chain elongation
HSF1 activation
Neutrophil degranulation
Protein methylation
Chaperone Mediated Autophagy
SARS-CoV-1 modulates host translation machinery
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
Drugs
Zinc
Guanosine-5'-Diphosphate
Copper
Artenimol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Cladribine
Diseases
GWAS
Trigger finger (
32740585
)
Interacting Genes
144 interacting genes:
ABTB2
ACTB
ALPL
ANKRD24
ANXA7
APLP1
AQP2
ARIH2
AXIN1
BBS1
BBS2
BBS4
BRMS1
BTBD2
CASP2
CCL18
CDC25A
CDKN1A
CEBPA
CKS2
CLIC6
COX17
CRADD
CRCT1
CREBBP
CSRP2
CTIF
DARS1
DCTN1
DIABLO
DLEU1
DNMT1
DNMT3A
DUSP7
DYNLL1
DYSF
EIF3F
EP300
EXOSC4
FAS
GADD45A
GADD45G
HOXA1
HSPB2
HSPE1
HTRA2
IKBKG
IMMT
ITGB1BP1
ITSN1
KCNE3
KIF1B
LAMA4
LAMTOR1
LAMTOR5
LSM3
MAD2L1BP
MAGED2
MAP3K14
MAPK14
MLLT3
MNAT1
MRM1
MRPL42
MTRNR2L1
MYOC
NEU1
NRAS
NREP
OGT
ORMDL3
PABPC4
PAEP
PAFAH1B3
PAPSS1
PCDHA4
PFN2
PHYHIP
PKN2
PLAUR
PLCG1
POLE2
POLR2C
PQBP1
PRKCD
PSG9
PSMD11
PTPN4
PTPRCAP
PTPRF
RAB27A
RAP2A
RFC5
RGS12
RND1
RNF10
RPA2
RPLP1
RRAS
RSRC1
SARS2
SDHAF2
SERPINB5
SERPINB9
SF3B4
SFN
SHBG
SMAD2
SMAD4
SMN1
SPATS2L
SPP1
SSR1
STAT6
STMN2
SULT1E1
SUMO2
TAF9
TGIF1
TK1
TMPRSS3
TNFSF11
TP53BP2
TPT1
TRDMT1
TSC2
TSPY1
TSPYL2
TTLL12
TTR
TXNIP
UBQLN4
USP40
VHL
WARS1
WEE2-AS1
XPO5
XRN2
YJU2B
YWHAG
ZBTB16
ZCCHC10
ZNF24
ZPR1
19 interacting genes:
AGFG1
BAIAP2L2
EEF1A1
ERG28
EXOSC4
KAT5
MAPRE1
PKM
POLE4
REL
SAP18
SORBS3
TBX15
TLE1
TRIM27
UBC
UBQLN2
ZBED1
ZNF620
Entrez ID
1915
5427
HPRD ID
00559
16007
Ensembl ID
ENSG00000156508
ENSG00000100479
Uniprot IDs
P68104
Q6IPS9
P56282
PDB IDs
3C5J
6ZMO
8G60
8G6J
2V6Z
5VBN
7PFO
7PLO
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Apoptotic Process
Cell Death
Programmed Cell Death
Regulation Of Programmed Cell Death
Cytosol
Negative Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Negative Regulation Of Kinase Activity
Negative Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Phosphorylation
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Apoptotic Signaling Pathway
BBSome
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
TORC1 Signaling
Protein-containing Complex
Nucleus
Macromolecule Biosynthetic Process
Melanosome Transport
Tau Protein Binding
Regulation Of Developmental Process
RNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Establishment Of Melanosome Localization
Pigment Granule Transport
Negative Regulation Of Protein Phosphorylation
Cellular Response To Stress
Melanosome Localization
Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Macromolecule Metabolic Process
Positive Regulation Of Apoptotic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pigment Granule Localization
Mitochondrial Intermembrane Space
Nucleoplasm
Protein Binding
Negative Regulation Of Catalytic Activity
Histone H3K27 Acetyltransferase Activity
Negative Regulation Of Phosphate Metabolic Process
TOR Signaling
Positive Regulation Of TOR Signaling
Regulation Of Phosphorus Metabolic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Synaptic Transmission, Dopaminergic
Positive Regulation Of Organelle Organization
Regulation Of Autophagy
Cytosol
Transcription Coactivator Activity
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Cytoskeleton Organization
Regulation Of Supramolecular Fiber Organization
Regulation Of DNA-templated Transcription
Auditory Receptor Cell Fate Determination
Regulation Of Macromolecule Biosynthetic Process
Auditory Receptor Cell Fate Specification
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Organelle Organization
RNA Binding
Ficolin-1-rich Granule Lumen
Secretory Granule Lumen
Identical Protein Binding
SUMO Transferase Activity
PML Body
Protein Autosumoylation
Histone H2AK5 Acetyltransferase Activity
Mitotic Spindle Pole
Establishment Of Mitotic Spindle Orientation
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Attachment Of Spindle Microtubules To Kinetochore
Glyoxal Catabolic Process
L-dopa Decarboxylase Activator Activity
Guanine Deglycation
Protein Deglycase Activity
Glyoxalase (glycolic Acid-forming) Activity
Glycolate Biosynthetic Process
Guanine Deglycation, Methylglyoxal Removal
Guanine Deglycation, Glyoxal Removal
Detoxification Of Mercury Ion
Negative Regulation Of Death-inducing Signaling Complex Assembly
Cellular Response To Glyoxal
Glyoxal Metabolic Process
Positive Regulation Of L-dopa Biosynthetic Process
Tyrosine 3-monooxygenase Activator Activity
Protein Localization To Astral Microtubule
Keratinocyte Apoptotic Process
Regulation Of RNA Metabolic Process
Establishment Of Mitotic Spindle Localization
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Tagcloud (Difference)
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Tagcloud (Intersection)
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