EEF1A1 and MNAT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EEF1A1	MNAT1
Gene Name		eukaryotic translation elongation factor 1 alpha 1	MNAT CDK-activating kinase assembly factor 1
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Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Extracellular Vesicular Exosome	Nucleoplasm Holo TFIIH Complex Cytoplasm
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Poly(A) RNA Binding	Protein Binding DNA-dependent ATPase Activity Zinc Ion Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein N-terminus Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Elongation Gene Expression Cellular Protein Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Complex Assembly Protein Phosphorylation Adult Heart Development Cell Proliferation Gene Expression Viral Process Ventricular System Development Regulation Of Gene Expression, Epigenetic Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Viral Transcription Response To Calcium Ion
Pathways		HSF1 activation Translation Cellular response to heat stress Peptide chain elongation Eukaryotic Translation Elongation	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		123 interactors: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCDC130 CCL18 CDC25A CDKN1A CKS2 COX17 CRADD CRCT1 CSRP2 DARS DIABLO DLEU1 DUSP7 DYNLL1 EIF3F EXOSC4 FAS GADD45A GADD45G GSK3B HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B KRAS LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP RAB27A RAP2A RBBP8 RFC5 RGS12 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB9 SFN SHBG SMAD2 SMAD4 SMN1 SNCA SPP1 SSR1 STAT6 STMN2 SULT1E1 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSPY1 TSPYL2 TTR UBQLN4 WARS XPO5 XRN2 YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1	42 interactors: BRCA1 CCNH CDK7 COPS6 CTD DMAP1 E2F1 EEF1A1 ERCC3 ESR1 GTF2E2 HPS6 LRIF1 MBP MCM7 MDM4 MKRN3 MTA1 NGFRAP1 NKX3-1 POLR2A POU2F1 POU2F2 POU5F1 RB1 RBM48 RNF32 RNF41 RNF7 SUPT5H TP53 TRIM17 TRIM2 TRIM21 TRIM26 TRIM31 TRIM34 TRIM39 TRIM5 TRIM9 TRIML1 USP2
Entrez ID		1915	4331
HPRD ID		00559	04042
Ensembl ID		ENSG00000156508	ENSG00000020426
Uniprot IDs		P68104 Q6IPS9	P51948
PDB IDs		1SYW	1G25
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Death Death Regulation Of Phosphorylation Developmental Process Regulation Of Phosphorus Metabolic Process Response To Stimulus Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Cell Differentiation Anatomical Structure Development Regulation Of Catalytic Activity Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Cell Death Multicellular Organismal Development Regulation Of Apoptotic Process Cellular Response To Stimulus Response To Stress Cellular Response To Growth Factor Stimulus Response To External Stimulus Positive Regulation Of Protein Modification Process Regulation Of Signaling Cellular Response To Stress Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Catalytic Activity System Development Positive Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Nervous System Development Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Kinase Activity	Regulation Of Transcription, DNA-templated Regulation Of Viral Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Viral Transcription Protein Ubiquitination Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Modification By Small Protein Conjugation Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Positive Regulation Of Viral Process 7-methylguanosine RNA Capping Transcription, DNA-templated DNA-templated Transcription, Elongation Regulation Of Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Viral Transcription Viral Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To DNA Damage Stimulus Regulation Of Viral Release From Host Cell Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Cycle Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Response To Stimulus Cellular Response To Stress Nucleotide-excision Repair Androgen Receptor Signaling Pathway RNA Metabolic Process Cellular Protein Modification Process Transcription-coupled Nucleotide-excision Repair
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a ube2v2
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a ube2v2
Tagcloud (Intersection) ?