EXOSC4 and DIS3

Number of citations of the paper that reports this interaction (PubMedID 20531386)
64

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (in vivo)

		EXOSC4	DIS3
Description		exosome component 4	DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	3'-5'-RNA Exonuclease Activity RNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity RNA Nuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Hydrolase Activity
	Biological Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process Nuclear MRNA Surveillance Of MRNA 3'-end Processing CUT Catabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163)	Restless legs syndrome ( 29029846)
Interacting Genes		34 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PRRC2B PTEN SDCBP SKIC2 SMPD4 TSEN15 UPF1 UPF2 UPF3B WTAP	13 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 RNF10 ZBTB17
Entrez ID		54512	22894
HPRD ID		16221	06338
Ensembl ID		ENSG00000178896	ENSG00000083520
Uniprot IDs		Q9NPD3	G3V1J5 Q9Y2L1
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Catabolic Process Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nuclear RNA Surveillance Nuclear MRNA Surveillance RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing MRNA Metabolic Process RRNA 3'-end Processing TRNA Decay SnRNA Metabolic Process RNA Metabolic Process Macromolecule Catabolic Process SnRNA 3'-end Processing RRNA Processing 3'-5'-RNA Exonuclease Activity RRNA Metabolic Process SnRNA Processing RNA Binding Nucleic Acid Metabolic Process CUT Catabolic Process RRNA Catabolic Process RNA 3'-end Processing Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression RNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Macromolecule Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolus Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Sno(s)RNA Metabolic Process TRNA Metabolic Process Exoribonuclease Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Processing RNA 3'-end Processing RRNA Catabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance RNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear-transcribed MRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process RRNA Processing Poly(A)-dependent SnoRNA 3'-end Processing MRNA Catabolic Process RRNA Metabolic Process RRNA 3'-end Processing 3'-5'-RNA Exonuclease Activity TRNA Decay Nucleobase-containing Compound Catabolic Process Sno(s)RNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA Processing Nucleolus MRNA 3'-UTR AU-rich Region Binding Catabolic Process DNA Deamination RNA Metabolic Process RNA Binding TRNA Metabolic Process Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA DNA Modification Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process SnRNA Catabolic Process
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