EXOSC4 and GTF2IRD1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		EXOSC4	GTF2IRD1
Gene Name		exosome component 4	GTF2I repeat domain containing 1
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Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding AU-rich Element Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Transition Between Slow And Fast Fiber
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LRRC8D MPP6 MPZL1 NEK1 SKIV2L SKIV2L2 SMPD4 TSEN15 UPF1 UPF2 UPF3B	6 interactors: CDK20 EXOSC4 HDAC3 PIAS2 SMAD3 UBC
Entrez ID		54512	9569
HPRD ID		16221	08379
Ensembl ID		ENSG00000178896	ENSG00000006704
Uniprot IDs		Q9NPD3	E9PFE2 Q9UHL9
PDB IDs		2NN6	2D99 2DN5 2DZQ 2DZR
Enriched GO Terms of Interacting Partners?		RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Maturation Of 5.8S RRNA RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing DNA Deamination Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome MRNA Export From Nucleus Metabolic Process	Regulation Of Cell Cycle Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus RNA Metabolic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Growth Gene Expression Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Osteoblast Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Stability Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Intracellular Protein Transport Evasion Or Tolerance Of Host Defenses By Virus Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Import Into Nucleus Circadian Rhythm Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Ossification Regulation Of Protein Localization To Nucleus Negative Regulation Of Apoptotic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death
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